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首页> 外文期刊>Environmental toxicology and chemistry >CHANGES IN ANTIBACTERIAL ACTIVITY OF TRICLOSAN AND SULFA DRUGS DUE TO PHOTOCHEMICAL TRANSFORMATIONS
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CHANGES IN ANTIBACTERIAL ACTIVITY OF TRICLOSAN AND SULFA DRUGS DUE TO PHOTOCHEMICAL TRANSFORMATIONS

机译：由于光化学转化，三氯生和硫磺类药物的抗菌活性发生变化

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摘要

Sulfa drugs and triclosan represent two classes of antibacterials that have been found in natural waters and for which photodegradation is anticipated to be a significant loss process. Parent antibacterial compounds and the products of photolysis reactions were compared for three sulfa drugs and triclosan to determine the extent to which photolysis affects their antibacterial potency on Escherichia coli DH5α. Sulfathiazole (median effective concentration [EC50] = 20.0 μM), sulfamethoxazole (EC50 = 12.3 μM), and sulfachloropyridazine (EC50 = 6.9 μM) inhibited bacterial growth but did not affect respiratory activity. Photolysis products of these sulfa drugs did not retain any measurable ability to inhibit growth. Triclosan inhibited both the growth (EC50 = 0.24 μM) and respiratory activity of E. coli DH5α. Triclosan photolysis products also exhibited no measurable effect on growth or respiratory activity. These experiments indicate that the products of triclosan and sulfa drug photolysis are unlikely to possess antibacterial activity in natural waters. The rapid screening method used for these two classes of compounds will be useful for helping to identify photolabile antibacterial compounds, for which photoproducts could require further investigation.
机译：磺胺类药物和三氯生是天然水中发现的两类抗菌剂，预计它们的光降解将是一个重大的损失过程。比较了三种磺胺药和三氯生的母体抗菌化合物及其光解反应产物，以确定光解影响它们对大肠杆菌DH5α的抗菌效力的程度。磺胺噻唑（中位数有效浓度[EC50] = 20.0μM），磺胺甲恶唑（EC50 = 12.3μM）和磺胺氯哒嗪（EC50 = 6.9μM）抑制细菌生长，但不影响呼吸活动。这些磺胺药物的光解产物没有保留任何可测量的抑制生长的能力。三氯生抑制大肠杆菌DH5α的生长（EC50 = 0.24μM）和呼吸活性。三氯生光解产物对生长或呼吸活动也没有表现出可测量的影响。这些实验表明三氯生和磺胺药物的光解产物在天然水中不太可能具有抗菌活性。用于这两类化合物的快速筛选方法将有助于鉴定对光不稳定的抗菌化合物，对于这些化合物，光产物可能需要进一步研究。

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