...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >Identification of compounds associated with testosterone depressions in fish exposed to bleached kraft pulp and paper mill chemical recovery condensates.
【24h】

Identification of compounds associated with testosterone depressions in fish exposed to bleached kraft pulp and paper mill chemical recovery condensates.

机译：在暴露于漂白的牛皮纸浆和造纸厂化学物质回收冷凝物中的鱼类中，与睾丸激素降低有关的化合物的鉴定。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In previous experiments, bleached kraft chemical recovery condensates generated during softwood pulp production have been identified as a primary source of substances causing testosterone depressions in mummichog (Fundulus heteroclitus). Recent toxicity identification evaluations have encountered inconsistencies in the potential of condensates and fractions to reduce steroid concentrations between three repeated exposures. To assess the sources of these inconsistencies, temporal assessments of condensate extractives and analytical methodologies were evaluated. Condensates were collected during a six-month period, extracted by solid-phase extraction (SPE), and analyzed by gas chromatography-mass spectrometry and gas chromatography-flame photometric detection. All unique extractives were cataloged by mass spectra, peak area, and gas chromatographic retention time, and nine were confirmed and quantified against authentic standards. Confirmed components included phenolic guaiacyl-based lignin degradation products, sulfur (S9), three diterpenoids, and a dimethoxy stilbene. Concentrations of confirmed condensate extractives were consistent in all samples collected. Spiking experiments of confirmed extractives revealed substantial losses following high-pressure liquid chromatographic fractionation and three different methods of fraction preparation. In an effort to propose chemical classes associated with biological activity, all unique condensate extractives in previously established bioactive and inactive fractions were classified based on their potential to depress testosterone in mummichog. Of 39 unique components in bioactive SPE extracts of condensates, six were associated with hormonal activity. Mass spectral interpretation indicated hydroxylated diterpenoids, sesquiterpenoids, and a lignin-derived stilbene as classes of chemicals associated with steroid depressions.
机译：在先前的实验中，已确认在软木纸浆生产过程中产生的漂白牛皮纸化学回收冷凝物是引起木乃伊（Fundulus heteroclitus）睾丸激素降低的主要物质来源。最近的毒性鉴定评估在冷凝物和馏分降低三次重复接触之间降低类固醇浓度的潜力方面存在不一致之处。为了评估这些不一致的根源，对冷凝液萃取物的时间评估和分析方法进行了评估。在六个月的时间内收集冷凝液，通过固相萃取（SPE）萃取，并通过气相色谱-质谱和气相色谱-火焰光度检测进行分析。通过质谱，峰面积和气相色谱保留时间对所有独特的萃取物进行分类，并根据真实标准品对9种萃取物进行了确认和定量。确认的成分包括酚类基于愈创木基的木质素降解产物，硫（S9），三种二萜类化合物和二甲氧基。在所有收集的样品中，确认的冷凝水萃取物的浓度均一致。经确认的萃取物的加标实验表明，高压液相色谱法分馏和三种不同的馏分制备方法会导致大量损失。为了提出与生物活性有关的化学类别，基于先前确定的生物活性和非活性馏分中所有独特的缩合物萃取物可降低木乃伊中睾丸激素的潜力进行分类。冷凝物具有生物活性的SPE提取物中的39种独特成分中，有6种与激素活性有关。质谱解释表明，羟基化的二萜，倍半萜和木质素衍生的二苯乙烯是与类固醇抑郁症相关的化学物质。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号