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首页> 外文期刊>Environmental toxicology and chemistry >Hepatic porphyria induced by the herbicide tralkoxydim in small mammals is species-specific.
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Hepatic porphyria induced by the herbicide tralkoxydim in small mammals is species-specific.

机译：除草剂traalkoxydim在小型哺乳动物中诱发的肝卟啉是种特异性的。

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Tralkoxydim is the active ingredient in a postemergent herbicide used in cereal crops. During preregistration trials, tralkoxydim was observed to cause hepatic porphyria and cholestasis in laboratory mice. Porphyria was not seen in similarly exposed rats or hamsters, but data were not collected regarding the susceptibility of any wild small mammal species to the tralkoxydim-induced porphyria. To address this data gap, we exposed small mammals to tralkoxydim, to 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC; a known porphyrinogenic chemical), or to sunflower oil alone. We studied small mammal species that might be exposed following agricultural applications of the herbicide, including the white-footed mouse (Peromyscus leucopus), the deer mouse (P. maniculatus), and the meadow vole (Microtus pennsylvanicus). Because of their known susceptibility to both tralkoxydim- and DDC-induced porphyria, commercially supplied Mus musculus (CD-1 Swiss mice) were exposed as positive-control animals. We also exposed offspring of wild-caught M. musculus to compare their responses to those of the commercially supplied animals. Potential hepatotoxicity was determined by assessing the accumulation of liver protoporphyrin. Of the species tested, only M. musculus was susceptible to the porphyrinogenic action of tralkoxydim, and no significant accumulation of protoporphyrin was observed in any of the other species exposed to the herbicide.
机译：Tralkoxydim是谷物作物中使用的芽后除草剂中的活性成分。在预注册试验期间，观察到traalkoxydim在实验室小鼠中引起肝卟啉症和胆汁淤积。在类似暴露的大鼠或仓鼠中未见卟啉症，但未收集任何野生小哺乳动物物种对四烷氧嘧啶引起的卟啉症的敏感性数据。为了解决此数据缺口，我们将小型哺乳动物暴露于三氟乙草胺，3,5-二乙氧基羰基-1,4-二氢可力丁（DDC；一种已知的致卟啉化学物质）或仅葵花籽油中。我们研究了除草剂在农业上应用后可能暴露的小型哺乳动物物种，包括白脚小鼠（Peromyscus leucopus），鹿小鼠（P. maniculatus）和草地田鼠（Microtus pennsylvanicus）。由于已知它们对曲烷氧基丁二酸和DDC诱导的卟啉症具有敏感性，因此将市售的小家鼠（CD-1瑞士小鼠）作为阳性对照动物暴露。我们还暴露了野生捕捞的小家鼠的后代，以比较它们与市售动物的反应。通过评估肝原卟啉的积累来确定潜在的肝毒性。在所测试的物种中，仅小家鼠对traalkoxydim的致卟啉作用敏感，在暴露于除草剂的任何其他物种中均未观察到原卟啉的大量积累。

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