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首页> 外文期刊>Environmental toxicology and chemistry >Determination of select antidepressants in fish from an effluent-dominated stream.
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Determination of select antidepressants in fish from an effluent-dominated stream.

机译：测定以废水为主的河流中鱼类中所选的抗抑郁药。

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摘要

Increasing evidence indicates widespread occurrence of pharmaceuticals and personal care products (PPCPs) in municipal effluent discharges and surface waters. Studies that characterize the fate and effects of PPCPs in aquatic systems are limited, and to our knowledge, data regarding pharmaceutical accumulation in fish of effluent-dominated ecosystems have not been previously reported. In the present study, fish populations were sampled from a reference stream and an effluent-dominated stream in north Texas, USA. Lepomis macrochirus, Ictalurus punctatus, Cyprinus carpio, and Pomoxis nigromaculatus were killed; the liver, brain, and lateral filet tissues dissected; and the tissues stored at -80 degrees C until analysis. Fish tissues were extracted using solid-phase extraction and then analyzed by gas chromatography-mass spectrometry in the negative chemical ionization mode. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and the SSRI metabolites norfluoxetine and desmethylsertraline were detected at levels greater than 0.1 ng/g in all tissues examined from fish residing in a municipal effluent-dominated stream. To our knowledge, the present study is the first report of SSRI residues in fish residing within municipal effluent-dominated systems.
机译：越来越多的证据表明，市政污水和地表水中普遍存在药品和个人护理产品（PPCP）。关于PPCP在水生系统中的命运和作用的特征的研究是有限的，据我们所知，以前尚未报道过以废水为主的生态系统中鱼类体内药物积累的数据。在本研究中，鱼类种群是从美国德克萨斯州北部的参考水流和以废水为主的水流中取样的。 Lepomis macrochirus，Ictalurus punctatus，Cyprinus carpio和Pomoxis nigromaculatus被杀死。解剖肝，脑和外侧菲力组织；并将组织储存在-80摄氏度下直至分析。用固相萃取法提取鱼的组织，然后以负化学电离模式通过气相色谱-质谱法进行分析。在居住于城市污水占主导地位的河流中检测的所有组织中，检测到的所有血清中选择性5-羟色胺再摄取抑制剂（SSRIs）氟西汀和舍曲林以及SSRI代谢物去氟西汀和去甲基舍曲林的含量均大于0.1 ng / g。据我们所知，本研究是生活在城市污水控制系统中的鱼类中SSRI残留的第一份报告。

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