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首页> 外文期刊>Environmental toxicology and chemistry >Detection and evaluation of endocrine-disruption activity in water samples from Portuguese rivers.
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Detection and evaluation of endocrine-disruption activity in water samples from Portuguese rivers.

机译：葡萄牙河流水样中内分泌干扰活性的检测和评估。

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Water samples (n = 183) from Portuguese rivers were tested for the presence of endocrine disruptors using the recombinant yeast assay (RYA) combined with chemical identification of compounds having endocrine-disruption properties by liquid chromatography coupled to mass spectrometry. Ten selected locations were sampled monthly for a period of 20 months, from April 2001 to December 2002. More than 90% of samples showed either no detectable or low levels of estrogenicity (<0.1 ng/L of estradiol equivalents). The remaining samples (17 in total, 9.3%) showed estrogenicity values ranging from 0.1 to 1.7 ng/L of estradiol equivalents; only two samples showed values greater than 1 ng/L of estradiol equivalents. Most highly estrogenic samples (13 of 17 samples) originated in five sampling sites clustered in two zones near Porto and Lisbon. Chemical analysis detected alkylphenolic compounds (octyl- and nonylphenol plus nonylphenol ethoxylates) in all samples, albeit at concentrations less than 1 microg/L for each compound in 80% of samples. Total analyte concentration exceeded 10 microg/L in only 10 samples, with all but one of those originating from only two sampling sites. In these two locations, a good correlation was observed between the concentrations of octylphenol, nonylphenol, and to a lesser extent, bisphenol A in the samples and their estrogenicity values as calculated by RYA. We conclude that estrogenic activity can be explained by alkylphenol contamination in only these sites; for the remainder, we propose that pesticides and urban waste may be the main factors responsible for estrogenic contamination.
机译：使用重组酵母测定法（RYA），结合液相色谱和质谱联用技术对具有内分泌干扰特性的化合物进行化学鉴定，测试了葡萄牙河流中的水样本（n = 183）是否存在内分泌干扰物。从2001年4月至2002年12月，每月在十个选定的地点进行采样，为期20个月。超过90％的样本显示未检测到雌激素水平或雌激素水平较低（雌二醇当量<0.1 ng / L）。其余样品（总共17个，占9.3％）的雌激素值在0.1-1.7 ng / L的雌二醇当量范围内。只有两个样品显示出大于1 ng / L的雌二醇当量值。大多数高雌激素性样品（17个样品中的13个）来自聚集在波尔图和里斯本附近两个区域的五个采样点。化学分析在所有样品中检测到烷基酚化合物（辛基和壬基酚加壬基酚乙氧基化物），尽管在80％的样品中每种化合物的浓度均低于1 microg / L。仅10个样品中的总分析物浓度超过10 microg / L，其中一个样品仅来自两个采样点。在这两个位置，观察到样品中辛基苯酚，壬基苯酚的浓度以及较小程度的双酚A的浓度与其通过RYA计算的雌激素值之间具有良好的相关性。我们得出的结论是，只有这些部位的烷基酚污染才能解释雌激素活性。对于其余部分，我们建议农药和城市废物可能是造成雌激素污染的主要因素。

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