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首页> 外文期刊>Environmental toxicology and chemistry >INDIVIDUAL AND COMBINED TOXICITY OF NITRILES AND ALDEHYDES TO RAPHIDOCELIS SUBCAPITATA
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INDIVIDUAL AND COMBINED TOXICITY OF NITRILES AND ALDEHYDES TO RAPHIDOCELIS SUBCAPITATA

机译：腈和醛对亚生红景天的个体和综合毒性

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摘要

A closed-system algal toxicity test with no headspace was applied to evaluate the toxicity of 11 aldehydes and two nitriles to Raphidocelis subcapitata. Algal growth rate and dissolved oxygen (DO) production were used as the test endpoints. Compared to literature data, our test results based on the endpoint of DO production is 2.5 to 257 times more sensitive than the conventional algal batch tests. In addition, our analyses show that different relative toxicity relationships may be observed when different test methods or different endpoints are applied. The test alga was found to be quite sensitive to aldehydes, and a quantitative structure-activity relationship (QSAR) relationship was established based on the n-octanol/water partition coefficient (log K_(OW)). This study also evaluated the combined effects of aldehydes and nitriles. Four synergistic joint actions related to malononitrile were identified. On the other hand, most of the combined effects between aldehydes and acetonitrile were antagonistic. In general, we find that greater-than-additive effects mainly are associated with toxicants displaying flat dose-response curves, and less-than-additive effects may be related to certain steep-slope chemicals. Model analyses show that the above mixture toxicity behavior may be due to response addition or response multiplication joint action modes.
机译：采用无顶空的封闭系统藻类毒性试验，以评估11种醛和2个腈类对小黑麦草的毒性。藻类生长速率和溶解氧（DO）产量用作测试终点。与文献数据相比，我们基于溶解氧生产终点的测试结果比常规藻类批次测试的灵敏度高2.5到257倍。此外，我们的分析表明，当采用不同的测试方法或不同的终点时，可能会观察到不同的相对毒性关系。发现测试藻对醛非常敏感，并基于正辛醇/水分配系数（log K_（OW））建立了定量构效关系（QSAR）关系。这项研究还评估了醛和腈的综合作用。确定了与丙二腈有关的四个协同关节作用。另一方面，醛和乙腈之间的大多数联合作用都是拮抗的。通常，我们发现，大于加性效应主要与显示平坦剂量反应曲线的毒物有关，而小于加性效应可能与某些陡坡化学品有关。模型分析表明，上述混合物的毒性行为可能是由于反应加法或反应倍增联合作用方式引起的。

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