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首页> 外文期刊>Environmental toxicology and chemistry >FISH CRITICAL CELLULAR RESIDUES FOR SURFACTANTS AND SURFACTANT MIXTURES
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FISH CRITICAL CELLULAR RESIDUES FOR SURFACTANTS AND SURFACTANT MIXTURES

机译：鱼表面活性剂和表面活性剂混合物的细胞残渣

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摘要

The feasibility of using in vitro methods to predict in vivo critical body residue (CBR) for single surfactants and mixtures by measuring the critical cell residue (CCR) in a hepatic fish cell line (PLHC-1C) was investigated. The CCR values were determined using radiochemical methods to measure the test compound partitioning between media and cells at varying concentrations for three distinctly different surfactants (anionic, cationic, and nonionic) and their mixture. The cell median effective concentration (EC50) values for hexadecyltrimethylammonium chloride (C_(16)TMAC), dodecyl hexaethoxylate (C_(12)E_6), and sodium dodecylbenzene sulfonate (C_(12)LAS) ranged from 2.9 to 163.3 μM, a 54-fold difference. These cell EC50 values indicate that the cells are several-fold less sensitive to surfactants than whole organisms are. However, based on cellular residue levels for each surfactant and their mixture, only an approximately threefold difference was observed with a range of 0.6 to 1.8 mmol/kg. These concentrations correspond closely to in vivo body burdens (0.2-8 mmol/kg) associated with nonpolar organic or narcosis-acting compounds and their mixtures. The CCRs could provide an alternative and rapid technique to predict CBRs.
机译：通过测量肝鱼细胞系（PLHC-1C）中的关键细胞残基（CCR），研究了使用体外方法预测单个表面活性剂和混合物的体内关键体残基（CBR）的可行性。使用放射化学方法测定CCR值，以测量三种不同表面活性剂（阴离子，阳离子和非离子）及其混合物在不同浓度下测试化合物在培养基和细胞之间的分配。十六烷基三甲基氯化铵（C_（16）TMAC），十二烷基六乙氧基化物（C_（12）E_6）和十二烷基苯磺酸钠（C_（12）LAS）的细胞中值有效浓度（EC50）范围为2.9至163.3μM，54倍的差异。这些细胞的EC50值表明，细胞对表面活性剂的敏感性比整个生物体低几倍。但是，基于每种表面活性剂及其混合物的细胞残留水平，仅观察到大约三倍的差异，范围为0.6至1.8 mmol / kg。这些浓度与与非极性有机或具有麻醉作用的化合物及其混合物相关的体内人体负荷（0.2-8 mmol / kg）密切相关。 CCR可以提供一种替代的快速技术来预测CBR。

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