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首页> 外文期刊>Environmental toxicology and chemistry >1,3-dinitrobenzene toxicity in the least shrew, Cryptotis parva.
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1,3-dinitrobenzene toxicity in the least shrew, Cryptotis parva.

机译：1,3-二硝基苯毒性最小，隐孢子虫。

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摘要

Shrews are abundant in most areas of toxic chemical contamination and bioaccumulate pollutants at much higher rates than sympatric rodent species. As a part of studies to provide information concerning the toxicity of 1,3-dinitrobenzene (DNB) in least shrews (Cryptotis parva), groups of 10 females and 10 males received DNB at 0 (control), 0.7, 2.9, 11.6, and 46.3 microl/L (equivalent mean daily dosage of 0, 0.26, 1.06, 4.26, and 17.0 mg/kg body wt in each sex) in their diet for 14 d. Leukocytosis present at the 0.26 mg/kg body weight/d dosage established the lowest-observed-adverse effect level (LOAEL). Adrenal enlargement was noted at the 1.06 mg/kg body weight/d level. Splenic enlargement and reductions in hematocrit and hemoglobin values occurred at the 4.26 mg/kg body weight/d treatment. Enlargements in the liver and heart and reductions in brown fat weight, granulocyte numbers, and alanine aminotransferase levels were present at high dose levels. Histopathologic examinations showed Kupffer's cell hemosiderosis and suggested testicular damage at the two highest tested doses but failed to confirm brain lesions. Least shrews do not follow standard scaling estimates for lifespan or metabolic rates. The LOAEL calculated from the standard terrestrial screening benchmark equation was higher than our findings, suggesting that these estimates must be viewed with caution.
机译：most在大多数有毒化学污染和生物蓄积性污染物领域中的含量都比同伴啮齿动物物种高得多。为了提供有关1,3-二硝基苯（DNB）在最少sh（Cryptotis parva）中毒性的信息的研究的一部分，每10个雌性和10个雄性的组在0（对照），0.7、2.9、11.6和0接受了DNB。饮食14 d时为46.3微升/升（每性别的平均日剂量分别为0、0.26、1.06、4.26和17.0 mg / kg体重）。以0.26 mg / kg体重/ d剂量存在的白细胞增多症建立了最低的观察到的不良反应水平（LOAEL）。肾上腺肿胀以1.06 mg / kg体重/ d的水平记录。在4.26 mg / kg体重/天的治疗量下，脾脏增大，血细胞比容和血红蛋白值降低。在高剂量水平下，肝脏和心脏肿大，棕色脂肪重量，粒细胞数量和丙氨酸氨基转移酶水平降低。组织病理学检查显示库普弗氏细胞含铁血黄素沉着症，并建议在两次最高测试剂量下睾丸受损，但未能证实脑部病变。最少的rew不遵循标准的寿命或新陈代谢率比例估计。根据标准地面筛选基准方程式计算的LOAEL高于我们的发现，这表明必须谨慎对待这些估计值。

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