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首页> 外文期刊>Environmental toxicology and chemistry >Toxicity of binary mixtures of cadmium-copper and carbendazim-copper to the nematode Caenorhabditis elegans.
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Toxicity of binary mixtures of cadmium-copper and carbendazim-copper to the nematode Caenorhabditis elegans.

机译：镉-铜和多菌灵-铜的二元混合物对线虫秀丽隐杆线虫的毒性。

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摘要

For ecological risk assessment, the additive model may be used to empirically predict toxic mixture effects. Detailed toxicity tests were performed to determine whether effects of mixtures of copper-cadmium and copper-carbendazim on Caenorhabditis elegans were similar to the effects of the individual compounds. Effects on the course of reproduction, the length of the juvenile period, the length of the reproductive period, and body length were analyzed. Dose-response data were compared to the additive model and tested for four deviation patterns from additivity: No deviation, synergistic/antagonistic deviation, dose ratio-dependent deviation, dose level-dependent deviation. During the exposure, the cadmium-copper effect on reproduction changed from a synergistic, to a dose ratio-dependent deviation from additivity. More cadmium in the mixture decreased the toxicity and more copper increased the toxicity. The effect of copper-carbendazim on reproduction was synergistic at low dose levels and antagonisticat high dose levels and independent of time. Mixture effects on the juvenile and reproductive period were similar to single component effects. It was concluded that the observed time-dependence of toxic interactions was small and that interactions on the timing of reproduction were not found. The additive model underestimated mixture effects on reproduction and body length.
机译：对于生态风险评估，可使用加性模型来凭经验预测有毒混合物的影响。进行了详细的毒性试验，以确定铜镉和多菌灵铜混合物对秀丽隐杆线虫的作用是否与单个化合物的作用相似。分析对生殖过程，幼年期的长度，生殖期的长度和体长的影响。将剂量反应数据与加性模型进行比较，并测试了可加性的四个偏差模式：无偏差，协同/拮抗偏差，剂量比依赖性偏差，剂量水平依赖性偏差。在暴露过程中，镉-铜对生殖的影响从协同作用变为与加和剂的剂量比相关偏差。混合物中更多的镉会降低毒性，而更多的铜会增加毒性。多菌灵铜对生殖的影响在低剂量水平具有协同作用，而在高剂量水平则具有拮抗作用，并且与时间无关。混合效应对幼年和生殖期的影响类似于单组分效应。结论是，观察到的毒性相互作用的时间依赖性很小，并且未发现相互作用对繁殖时间的影响。加性模型低估了混合对生殖和体长的影响。

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