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首页> 外文期刊>Environmental toxicology and chemistry >EVALUATION OF BIOMARKERS OF EXPOSURE AND EFFECT IN JUVENILE AREOLATED GROUPER (EPINEPHELUS AREOLATUS) ON FOODBORNE EXPOSURE TO BENZO[a]PYRENE
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EVALUATION OF BIOMARKERS OF EXPOSURE AND EFFECT IN JUVENILE AREOLATED GROUPER (EPINEPHELUS AREOLATUS) ON FOODBORNE EXPOSURE TO BENZO[a]PYRENE

机译：幼年斑纹石斑鱼（EBINEPHELUS AREOLATUS）接触苯并[a] P的食物中生物标志物的评估

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摘要

Food-borne benzo[a]pyrene (B[a]P) was administered daily to juvenile grouper (Epinephelus areolatus) at two environmentally realistic concentrations (a low dose of 0.25 μg B[a]P/g body wt/d and a high dose of 12.5 μg B[a]P/g body wt/d) to investigate and relate temporal changes in body burden of B[a]P, hepatic ethoxyresorufin-O-deethylase (EROD) activities, growth, RNA:DNA ratio, estradiol, testosterone, and triiodothyronine (T3). After feeding with B[a]P diets for four weeks, fish were fed with normal diet for another four weeks to study recovery of the various biomarkers during the depuration period. After one week of exposure, both body muscle B[a]P burdens and hepatic EROD activities significantly increased. Body burdens were stable in tissues until the fourth week of exposure, when concentrations in the high-dose group increased markedly, at which time a concomitant decrease in EROD was found. During the depuration period, body burdens decreased in the second week, and EROD declined in the first week. Growth and RNA:DNA ratio were unaltered. Despite large variations found in sex steroid levels, elevation of testosterone was clearly evident in the fourth week, showing that B[a]P may disrupt the balance of sex steroids in fish. Significantly, increases in plasma-free T3 concentrations were found in the fourth week of exposure and the first week of depuration, suggesting that development and reproduction may potentially be at risk during chronic exposures. Our data also suggest that these hormonal disturbances are not persistent and that normal hormonal levels can be restored soon after contamination is abated.
机译：每天以两种环境上可行的浓度（0.25克低剂量的B [a] P / g体重/ d和1毫克/ kg的体重）将食源性苯并[a] py（B [a] P）施用给少年石斑鱼（Epinephelus areolatus）。高剂量的12.5μgB [a] P / g体重/ d），以研究并关联B [a] P的体内负荷的时间变化，肝乙氧基反刍蛋白-O-脱乙基酶（EROD）活性，生长，RNA：DNA比，雌二醇，睾丸激素和三碘甲状腺素（T3）。用B [a] P饲料喂养四周后，再用正常饲料喂养鱼四周，以研究净化期间各种生物标记物的恢复情况。接触一周后，人体肌肉的B [a] P负担和肝EROD活性均显着增加。直到接触的第四个星期，高剂量组的浓度显着增加，组织中的身体负担才稳定，此时发现EROD随之降低。在净化期间，身体负担在第二周下降，而EROD在第一周下降。生长和RNA：DNA比例未改变。尽管发现性类固醇水平存在较大差异，但在第四周睾丸激素水平明显升高，这表明B [a] P可能会破坏鱼类中性类固醇的平衡。值得注意的是，在暴露的第四周和净化的第一周发现无血浆T3浓度增加，这表明在长期暴露过程中发育和繁殖可能处于危险之中。我们的数据还表明，这些荷尔蒙紊乱不是持久性的，污染减轻后可以很快恢复正常的荷尔蒙水平。

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