QUANTITATIVE STRUCTURE―ACTIVITY RELATIONSHIPS FOR PREDICTING SKIN AND RESPIRATORY SENSITIZATION

ROSEMARY RODFORD; GRACE PATLEWICZ; JOHN D. WALKER; MARTIN P. PAYNE

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QUANTITATIVE STRUCTURE―ACTIVITY RELATIONSHIPS FOR PREDICTING SKIN AND RESPIRATORY SENSITIZATION

机译：预测皮肤和呼吸道敏感性的定量结构-活性关系

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Quantitative structure-activity relationships (QSARs) for predicting skin and respiratory sensitization are reviewed. Overall, progress has been hampered by the sparseness of good quality experimental data, a fact that makes it difficult, at this time, to recommend one or two QSARs for predicting skin and respiratory sensitization. Creation of appropriate data sets for uninvestigated classes of chemicals by experimentation should facilitate the development of more robust QSARs for predicting skin and respiratory sensitization. Such QSARs will be valuable in the evaluation of identifiable toxic hazards where dose responses are relevant, as is the case for skin and respiratory sensitization.

机译：定量结构-活性关系（QSARs）预测皮肤和呼吸道的敏感性进行了审查。总体而言，高质量实验数据的稀疏阻碍了进展，这一事实使得目前很难推荐一个或两个QSAR来预测皮肤和呼吸道致敏性。通过实验为未研究的化学品类别创建适当的数据集，应有助于开发更强大的QSAR，以预测皮肤和呼吸道致敏性。这样的QSAR在评估与剂量反应相关的可识别的毒性危害方面将是有价值的，如皮肤和呼吸道致敏的情况。

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《Environmental toxicology and chemistry》 |2003年第8期|p.1855-1861|共7页
作者
ROSEMARY RODFORD; GRACE PATLEWICZ; JOHN D. WALKER; MARTIN P. PAYNE;
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作者单位

Solo Star, 19 Spinney Road, Chawston, Bedford, Bedfordshire MK44 3BW, United Kingdom;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境卫生、环境医学;毒物学（毒理学）;化学工业废物处理与综合利用;
关键词
structure―activity relationship relative alkylation index expert system local lymph node assay guinea pig maximization;

机译：结构-活性关系相对烷基化指数专家系统局部淋巴结试验豚鼠最大化;

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1. Quantitative structure-activity and quantitative structure-property relationship approaches as alternative skin sensitization risk assessment methods [J] . Ji Yun Kim, Min Kook Kim, Kyu-Bong Kim, Journal of toxicology and environmental health, Part A . 2019,第7a12期

机译：作为替代皮肤致敏风险评估方法的定量结构 - 活性和定量结构性质关系方法
2. A Respiratory Sensitization Study by a New Quantitative Structure-Activity Relationships (QSAR) [J] . Kazuhiro Sato, Tomohiro Umemura, Taro Tamura, Alternatives to Animal Testing and Experimentation . 2010,第3期

机译：通过新的定量构效关系（QSAR）进行呼吸敏化研究
3. Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships [J] . Luechtefeld Thomas, Maertens Alexandra, McKim James M., Journal of applied toxicology . 2015,第11a12期

机译：通过使用特征消除而不是定量的构效关系的剂量反应模型，对皮肤致敏力的概率危险评估
4. Predicting skin permeability of chemical substances using a quantitative structure-activity relationship [C] . Yen-Ching CHANG, Chen-Peng CHEN, Chan-Cheng CHEN International Symposium on Safety Science and Technology . 2013

机译：使用定量结构 - 活性关系预测化学物质的皮肤渗透性
5. Integration of quantitative structure-activity relationships and ecological survivorship modeling to predict chronic toxicity to fish and amphibians. [D] . Spromberg, Julann Aline. 2002

机译：整合定量构效关系和生态生存模型，以预测对鱼类和两栖动物的慢性毒性。
6. Probabilistic hazard assessment for skin sensitization potency by dose–response modeling using feature elimination instead of quantitative structure–activity relationships [O] . Thomas Luechtefeld, Alexandra Maertens, James M. McKim, -1

机译：通过使用特征消除而不是定量的结构-活动关系的剂量反应模型对皮肤致敏力的概率危险评估
7. Predicting Skin Permeability of Chemical Substances using a Quantitative Structure-activity Relationship [O] . Chang, Yen-Ching 2014

机译：使用定量构效关系预测化学物质的皮肤渗透性
8. Development of Quantitative Structure-Activity Relationships for Predicting Biodegradation Kinetics [R] . Desai, S. M., Govind, R., Tabak, H. H. 1990

机译：开发定量构效关系预测生物降解动力学

QUANTITATIVE STRUCTURE―ACTIVITY RELATIONSHIPS FOR PREDICTING SKIN AND RESPIRATORY SENSITIZATION

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