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首页> 外文期刊>Environmental toxicology and chemistry >TIME-DEPENDENT TOXICOKINETICS OF [~(14)C]LINDANE IN THE TERRESTRIAL ISOPOD PORCELLIONIDES PRUINOSUS
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TIME-DEPENDENT TOXICOKINETICS OF [~(14)C]LINDANE IN THE TERRESTRIAL ISOPOD PORCELLIONIDES PRUINOSUS

机译：[〜（14）C]林丹在时空异丙醇类丙酮中的时效毒理动力学

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摘要

Preliminary acute soil toxicity tests are a starting point for risk assessment. These tests are performed at one exposure time and are used to estimate the lethal concentration for 50% of the population (LC50). However, it is known that LC50 varies over time, following an exponential decay model. Here, we present the variation of LC50 over time in the isopod Porcellionides pruinosus exposed to [~(14)C]lindane when considering the concentrations measured in bulk soil and in extracted water. Using a wide range of concentrations, the percent mortality was recorded over various time intervals. Higher concentrations strongly influenced isopod survival. The LC50∞ value for P. pruinosus was 3.57 μg/g for bulk soil concentration, suggesting a great sensitivity of this species to lindane. Simultaneously, the values estimated for the lethal body concentration (LBC) were 2.36 μg/g animal for bulk soil concentrations and 2.79 μg/g animal when extracted water concentrations are considered. An alternative to the LC50 determination is the estimation of LBC, which is proposed as a better way to describe the acute toxicity of chemicals. Kinetic-based toxicity models were fitted to the data and revealed uptake rate constants of 1.1 g soil/g animal/week and 84.3 ml extracted water/g animal/week for bulk soil and extracted water concentrations, respectively. Elimination rate constants of 1.7 per week were found for both pathways of exposure.
机译：初步的急性土壤毒性测试是风险评估的起点。这些测试在一个暴露时间进行，用于估计50％人口的致死浓度（LC50）。但是，众所周知，LC50遵循指数衰减模型随时间变化。在这里，当考虑在散装土壤和提取水中测得的浓度时，我们展示了暴露于[〜（14）C]林丹的异足梭状紫菜的LC50随时间的变化。使用各种浓度的浓度，记录了不同时间间隔的死亡率百分比。较高的浓度强烈影响等足动物的生存。散装土壤中浓度为P. pruinosus的LC50∞为3.57μg/ g，表明该物种对林丹具有很高的敏感性。同时，估计的致死体浓度（LBC）值为2.36μg/ g动物（散装土壤），而当考虑提取水的浓度时为2.79μg/ g动物。 LC50测定的一种替代方法是估算LBC，这是描述化学品急性毒性的一种更好的方法。将基于动力学的毒性模型拟合到数据，并揭示了散装土壤和提取水浓度的摄取速率常数分别为1.1 g土壤/ g动物/周和84.3 ml提取水/ g动物/周。两种接触途径的消除速率常数均为每周1.7。

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