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首页> 外文期刊>Environmental toxicology and chemistry >EVIDENCE OF OXIDATIVE STRESS IN BLUEGILL SUNFISH (LEPOMIS MACROCHIRUS) LIVER MICROSOMES SIMULTANEOUSLY EXPOSED TO SOLAR ULTRAVIOLET RADIATION AND ANTHRACENE
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EVIDENCE OF OXIDATIVE STRESS IN BLUEGILL SUNFISH (LEPOMIS MACROCHIRUS) LIVER MICROSOMES SIMULTANEOUSLY EXPOSED TO SOLAR ULTRAVIOLET RADIATION AND ANTHRACENE

机译：同时暴露于太阳紫外线辐射和蒽的蓝SUNSunfish（LEPOMIS MACROCHIRUS）肝微粒体中的氧化应激证据

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摘要

Many polycyclic aromatic hydrocarbons (PAHs) are acutely toxic to fish and other aquatic organisms in the presence of environmentally realistic intensities of solar ultraviolet radiation (SUVR). However, the biochemical mechanism of this toxicity is not well established. In this study, increased levels of both reactive oxygen species production and lipid peroxidation were hypothesized as a toxic mechanism. To test this hypothesis, the production of superoxide anion and of a lipid peroxidation product (malondialdehyde) was measured in bluegill sunfish (Lepomis machrochirus) liver microsomes. These microsomes were exposed to a representative phototoxic PAH (anthracene [ANT]) and to SUVR and normal laboratory fluorescent light (FLU) in four different combinations: FLU + no ANT, FLU + ANT, SUVR + no ANT, and SUVR + ANT The highest mean levels of both superoxide anion and malondialdehyde production were observed in the SUVR + ANT group, and these levels were significantly different (p < 0.05) from those in all other treatment groups. We conclude that the photoinduced toxicity of ANT, and possibly of other phototoxic PAHs, manifests at least in part through lipid peroxidation after increased production of reactive oxygen species.
机译：在环境现实强度的太阳紫外线辐射（SUVR）的存在下，许多多环芳烃（PAH）对鱼类和其他水生生物具有剧毒。但是，这种毒性的生化机理尚未完全确立。在这项研究中，活性氧的产生和脂质过氧化的增加均被认为是一种毒性机制。为了检验这一假设，在blue鱼翻车鱼（Lepomis machrochirus）肝微粒体中测量了超氧阴离子和脂质过氧化产物（丙二醛）的产生。这些微粒体以四种不同的组合暴露于代表性的光毒性PAH（蒽[ANT]）和SUVR和正常实验室荧光灯（FLU）中：FLU +无ANT，FLU + ANT，SUVR +无ANT和SUVR + ANT。在SUVR + ANT组中观察到最高的超氧阴离子和丙二醛平均水平，并且这些水平与所有其他治疗组的水平显着不同（p <0.05）。我们得出结论，在活性氧的产生增加后，ANT和其他可能的光毒性PAHs的光诱导毒性至少部分通过脂质过氧化表现出来。

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