...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >GONADAL DEVELOPMENT AND ENDOCRINE RESPONSES IN JAPANESE MEDAKA (ORYZIAS LATIPES) EXPOSED TO o,p'-DDT IN WATER OR THROUGH MATERNAL TRANSFER
【24h】

GONADAL DEVELOPMENT AND ENDOCRINE RESPONSES IN JAPANESE MEDAKA (ORYZIAS LATIPES) EXPOSED TO o,p'-DDT IN WATER OR THROUGH MATERNAL TRANSFER

机译：暴露于水中或通过物质转移的邻，对'-DDT的日本中型（稻谷）的性腺发育和内分泌反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Various isomers and metabolites of DDT disrupt endocrine systems and gonadal development in fish and wildlife, and o,p'-DDT has been shown to be an relatively potent estrogen agonist. In this study, we exposed Japanese medaka (Oryzias latipes) to o,p'-DDT using two exposure protocols: direct exposure of early life stages to aqueous solutions from 1 to 100 d posthatch and exposure of female medaka to aqueous solutions, followed by mating with unexposed males to produce offspring that were exposed through mechanisms of maternal transfer. In treatments with direct aqueous exposures, an intersex condition of the gonad (testis- ova) was observed in male medaka exposed at early life stages to nominal o,p'-DDT concentrations of 50, 10, and 5 ug/L, indicating that this estrogen agonist can alter gonadal development when exposure occurs continuously over the period of gonadal differentiation. Comparisons with previously published data on the induction of testis-ova by exposure to nonylphenol (NP) and octylphenol (OP) indicated that the relative potencies for induction of intersex in medaka are o,p'-DDT De NP ≈ OP, which is not consistent with the relative estrogenic potencies of OP > NP > o,p'-DDT observed in the yeast estrogen screening (YES) assay. In the maternal transfer protocol, no testis-ova were observed in the offspring, although there was some delay in time to hatch of the offspring. Medaka exposed by maternal transfer showed no other toxicological responses during early life stages, but when treated fish reached sexual maturity, the females showed more advanced developme
机译：DDT的各种异构体和代谢产物破坏了鱼类和野生生物的内分泌系统和性腺发育，o，p'-DDT被证明是一种相对有效的雌激素激动剂。在这项研究中，我们使用两种暴露方案将日本med（Oryzias latipes）暴露于o，p'-DDT：孵化后1至100 d直接将生命早期阶段暴露于水溶液中，然后将雌性medaka暴露于水溶液中，与未暴露的雄性交配产生后代，这些后代通过母体转移机制暴露。在直接暴露于水的处理中，在生命早期暴露于标称o，p'-DDT浓度为50、10和5 ug / L的雄性花aka中观察到性腺（睾丸）为性交状态。当在性腺分化期间持续发生暴露时，这种雌激素激动剂可以改变性腺发育。通过与壬基酚（NP）和辛基酚（OP）接触引起的睾丸卵诱导与以前发表的数据进行比较，结果表明，在高中，诱导双性恋的相对能力为o，p'-DDT De NP≈OP，但不是与在酵母雌激素筛选（YES）试验中观察到的OP> NP> o，p'-DDT的相对雌激素潜能相符。在母体转移方案中，尽管后代孵化时间有所延迟，但在后代中未观察到睾丸卵。通过母体转移暴露的Medaka在生命的早期没有其他毒理学反应，但是当经过处理的鱼达到性成熟时，雌性显示出更高级的发育。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号