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首页> 外文期刊>Environmental toxicology and chemistry >Polycyclic Aromatic Hydrocarbons Alter the Hepatic Expression of Genes Involved in Sanderling (Calidris alba) Pre-migratory Fueling
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Polycyclic Aromatic Hydrocarbons Alter the Hepatic Expression of Genes Involved in Sanderling (Calidris alba) Pre-migratory Fueling

机译:多环芳烃改变涉及桑德林(Calidris Alba)前迁移速度的基因的肝脏表达

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摘要

Polycyclic aromatic hydrocarbons (PAHs) impaired pre-migratory fueling in 49 orally dosed Sanderling (Calidris alba). In the present study, 8 genes related to fat deposition and PAH exposure were measured in liver subsamples from these same shorebirds. At the highest dose (1260 mu g total PAH [tPAH]/kg body wt/day), PAH exposure decreased liver basic fatty acid binding protein 1 (Lbfabp) and hepatic lipase (Lipc) expression. The present study reveals candidate molecular-level pathways for observed avian pre-migratory refueling impairment. (c) 2021 SETAC
机译:多环芳烃(PAHS)在49个口服桑德林(Calidris Alba)中的迁移前加油预迁移燃料受损。 在本研究中,在来自这些相同的岸鸟的肝脏归档中测量了与脂肪沉积和PAH暴露有关的8个基因。 在最高剂量(1260μg总PAH [TPAH] / kg体WT /天),PAH暴露降低肝脏碱性脂肪酸结合蛋白1(LBFABP)和肝脂肪酶(LIPC)表达。 本研究揭示了观察到的禽类预加油损伤的候选分子水平途径。 (c)2021 Setac

著录项

  • 来源
    《Environmental toxicology and chemistry》 |2021年第7期|1981-1989|共9页
  • 作者单位

    Birds Canada Long Point Waterfowl & Wetlands Res Program Port Rowan ON Canada|Acadia Univ Biol Dept Wolfville NS Canada;

    Carleton Univ Natl Wildlife Res Ctr Environm & Climate Change Canada Ecotoxicol & Wildlife Hlth Div Ottawa ON Canada;

    Carleton Univ Natl Wildlife Res Ctr Environm & Climate Change Canada Ecotoxicol & Wildlife Hlth Div Ottawa ON Canada;

    Univ Saskatchewan Dept Biol Saskatoon SK Canada|Univ Saskatchewan Sch Environm & Sustainabil Saskatoon SK Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Avian toxicology; Gene expression; Polycyclic aromatic hydrocarbons; Pre-migratory fueling; Shorebird; Staging;

    机译:禽毒理学;基因表达;多环芳烃;迁移前的燃料;Shorebird;暂存;

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