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首页> 外文期刊>Environmental toxicology and chemistry >Sex‐ and Developmental Stage–Related Differences in the Hepatic Transcriptome of Japanese Quail (Coturnix japonica) Exposed to 17β‐Trenbolone
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Sex‐ and Developmental Stage–Related Differences in the Hepatic Transcriptome of Japanese Quail (Coturnix japonica) Exposed to 17β‐Trenbolone

机译：日本鹌鹑（CoTurnix japonica）暴露于17β-甲酮的性别和发育阶段相关差异

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摘要

Endocrine-disrupting chemicals can cause transcriptomic changes that may disrupt biological processes associated with reproductive function including metabolism, transport, and cell growth. We investigated effects from in ovo and dietary exposure to 17 beta-trenbolone (at 0, 1, and 10 ppm) on the Japanese quail (Coturnix japonica) hepatic transcriptome. Our objectives were to identify differentially expressed hepatic genes, assess perturbations of biological pathways, and examine sex- and developmental stage-related differences. The number of significantly differentially expressed genes was higher in embryos than in adults. Male embryos exhibited greater differential gene expression than female embryos, whereas in adults, males and females exhibited similar numbers of differentially expressed genes (2-fold). Vitellogenin and apovitellenin-1 were up-regulated in male adults exposed to 10 ppm 17 beta-trenbolone, and these birds also exhibited indications of immunomodulation. Functional grouping of differentially expressed genes identified processes including metabolism and transport of biomolecules, enzyme activity, and extracellular matrix interactions. Pathway enrichment analyses identified as perturbed peroxisome proliferator-activated receptor pathway, cardiac muscle contraction, gluconeogenesis, growth factor signaling, focal adhesion, and bile acid biosynthesis. One of the primary uses of 17 beta-trenbolone is that of a growth promoter, and these results identify effects on mechanistic pathways related to steroidogenesis, cell proliferation, differentiation, growth, and metabolism of lipids and proteins. Environ Toxicol Chem 2021;00:1-12. (c) 2021 SETAC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
机译：内分泌破坏化学物质会导致可能破坏与生殖功能相关的生物过程的转录组改变，包括代谢，运输和细胞生长。我们在日本鹌鹑（CoTurnix japonica）肝转录组上的ovo和膳食暴露于17β-甲酮（0,1和10ppm）中的影响。我们的目标是鉴定差异表达肝脏基因，评估生物途径的扰动，并检查性和发育阶段相关的差异。胚胎的显着差异表达基因的数量高于成人。雄性胚胎表现出比雌性胚胎更大的差异基因表达，而在成人中，雄性和女性表现出类似的差异表达基因（＆ 2倍）。将vitellogenin和Apovitellenin-1在暴露于10ppm 17β-甲肾上腺酮的雄性成虫中调节，这些鸟类还表现出免疫调节的适应症。差异表达基因的功能分组鉴定了包括代谢和生物分子的代谢，酶活性和细胞外基质相互作用的方法。途径富集分析鉴定为扰动过氧化物酶体增殖物激活受体途径，心肌收缩，葡糖生成，生长因子信号传导，局灶性粘附和胆汁酸生物合成。 17个β-霉耳的主要用途是生长促进剂的主要用途，这些结果识别与脂质和蛋白质的甾体素，细胞增殖，分化，生长和代谢相关的机械途径的影响。环境毒素化学2021; 00：1-12。 （c）2021 Setac。本文为美国政府员工贡献，他们的工作是美国的公共领域。

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