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Infra-familial spread of hepatitis B virus infection in eastern Turkey

机译:乙型肝炎病毒感染在家庭中的传播在土耳其东部

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摘要

Hepatitis B virus (HBV) infection is a worldwide health problem. The aim of the present study was not only to determine the prevalence of HBsAg in children of HBV-infected parents but also to identify all HBSAg-positive family members to protect as many children, in the present and future, as possible. The study was carried out with the participation of 2113 family members (1205 children, 453 mothers, and 455 fathers) at Sivas SSK Hospital, Turkey. They were screened for HBV markers using standard enzyme immunoassay between September 2001 and March 2005. The prevalence of any HBV markers and HBsAg among family members of index cases was 50·5% and 30·5% respectively. HBsAg carrier rate was higher among fathers (61 %) than mothers (47%), (P < 0·05). The children of mother index cases had higher rates of HBsAg compared with the children of father index cases (P < 0·01). Our results suggest that intra-familial childhood horizontal transmission (especially mother-to-child) is important for HBV transmission in the Turkish community, and highlights the need for screening of adult siblings and mothers of adult HBsAg carriers in addition to their spouses and children.
机译:乙型肝炎病毒(HBV)感染是全球性的健康问题。本研究的目的不仅是确定感染HBV的父母的孩子中HBsAg的患病率,而且是确定所有HBSAg阳性家庭成员以在当前和将来尽可能多地保护儿童。这项研究是在土耳其Sivas SSK医院的2113名家庭成员(1205名儿童,453名母亲和455名父亲)的参与下进行的。在2001年9月至2005年3月之间,使用标准酶免疫法对他们进行了HBV标志物筛选。在索引病例的家庭成员中,任何HBV标志物和HBsAg的患病率分别为50·5%和30·5%。父亲(61%)的HBsAg携带率高于母亲(47%),(P <0·05)。母亲指数病例的孩子的HBsAg发生率高于父亲指数病例的孩子(P <0·01)。我们的研究结果表明,家庭内部儿童时期水平传播(尤其是母婴传播)对于土耳其社区中的HBV传播很重要,并强调除了其配偶和子女外,还需要筛查成年兄弟姐妹和成年HBsAg携带者的母亲。 。

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