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首页> 外文期刊>Epidemiology and Infection >Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection
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Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection

机译：来自偏远原住民社区的化脓性链球菌的分子分型，风湿热很常见，脓皮病是主要的链球菌感染

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摘要

Aboriginal Australians in remote communities have high rates of rheumatic heart disease (RHD); yet pharyngitis is reportedly rare whilst pyoderma is common. Some strains of group A streptococci (GAS) have preference for the throat and others for the skin depending on M protein type. A study in three remote communities provided 350 GAS isolates for emm sequence typing, 244 were also emm pattern typed. There was 100% correlation between emm sequence and pattern type. Patterns D and E (non-throat tropic) made up 71 % of throat and 87 % of skin isolates although patterns A-C (throat tropic) were more common in the throat than the skin (RR 23, 95 % CI 1·4-3·8) whilst the opposite was found for pattern D (RR 2·2, 95% CI 1·7-3·0). Pattern E favoured the throat (RR 1·4, 95% CI 1·1-1·8). Where environmental factors predispose to skin infection, emm pattern types D and E prevail, whatever the recovery site.
机译：偏远社区的澳大利亚原住民风湿性心脏病（RHD）发病率很高；然而据报道咽炎很少见，而脓皮病很常见。根据M蛋白类型的不同，A组链球菌（GAS）的某些菌株更偏爱喉咙，其他菌株更偏爱皮肤。在三个偏远社区的一项研究提供了350种GAS分离株用于emm序列分型，其中244种还进行了mmh模式分型。 emm序列与模式类型之间存在100％的相关性。模式D和E（非喉咙性）占喉咙的71％，占皮肤分离物的87％，尽管模式AC（喉咙性）在喉咙中比皮肤更常见（RR 23，95％CI 1·4-3） ·8），而模式D（RR 2·2，95％CI 1·7-3·0）则相反。模式E偏爱喉咙（RR 1·4，95％CI 1·1-1·8）。在环境因素容易引起皮肤感染的地方，无论恢复地点如何，D型和E型Emm模式都占优势。

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