...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Archives of Psychiatry and Clinical Neuroscience >The N1 auditory evoked potential component as an endophenotype for schizophrenia: high-density electrical mapping in clinically unaffected first-degree relatives, first-episode, and chronic schizophrenia patients
【24h】

The N1 auditory evoked potential component as an endophenotype for schizophrenia: high-density electrical mapping in clinically unaffected first-degree relatives, first-episode, and chronic schizophrenia patients

机译：N1听觉诱发电位成分作为精神分裂症的内表型：临床上未受影响的一级亲属，首发和慢性精神分裂症患者的高密度电定位

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The N1 component of the auditory evoked potential (AEP) is a robust and easily recorded metric of auditory sensory-perceptual processing. In patients with schizophrenia, a diminution in the amplitude of this component is a near-ubiquitous finding. A pair of recent studies has also shown this N1 deficit in first-degree relatives of schizophrenia probands, suggesting that the deficit may be linked to the underlying genetic risk of the disease rather than to the disease state itself. However, in both these studies, a significant proportion of the relatives had other psychiatric conditions. As such, although the N1 deficit represents an intriguing candidate endophenotype for schizophrenia, it remains to be shown whether it is present in a group of clinically unaffected first-degree relatives. In addition to testing first-degree relatives, we also sought to replicate the N1 deficit in a group of first-episode patients and in a group of chronic schizophrenia probands. Subject groups consisted of 35 patients with schizophrenia, 30 unaffected first-degree relatives, 13 first-episode patients, and 22 healthy controls. Subjects sat in a dimly lit room and listened to a series of simple 1,000-Hz tones, indicating with a button press whenever they heard a deviant tone (1,500 Hz; 17% probability), while the AEP was recorded from 72 scalp electrodes. Both chronic and first-episode patients showed clear N1 amplitude decrements relative to healthy control subjects. Crucially, unaffected first-degree relatives also showed a clear N1 deficit. This study provides further support for the proposal that the auditory N1 deficit in schizophrenia is linked to the underlying genetic risk of developing this disorder. In light of recent studies, these results point to the N1 deficit as an endophenotypic marker for schizophrenia. The potential future utility of this metric as one element of a multivariate endophenotype is discussed.
机译：听觉诱发电位（AEP）的N1成分是一种健壮且易于记录的听觉感觉-知觉处理指标。在精神分裂症患者中，该成分的幅度减小是几乎普遍存在的发现。一对最新研究还显示，精神分裂症先证者的一级亲属中存在这种N1缺陷，表明该缺陷可能与疾病的潜在遗传风险有关，而不是与疾病状态本身有关。然而，在这两项研究中，相当多的亲戚患有其他精神病。因此，尽管N1缺乏症代表精神分裂症的一种有趣的候选内表型，但仍有待证明它是否存在于一组临床上未受影响的一级亲属中。除了测试一级亲属外，我们还试图在一组首发患者和一组慢性精神分裂症先证者中复制N1缺陷。受试者组包括35位精神分裂症患者，30位未受影响的一级亲属，13位首发患者和22位健康对照。受试者坐在昏暗的房间里，聆听一系列简单的1,000 Hz音调，每当他们听到异常的音调（1,500 Hz； 17％的概率）时都按下按钮，同时从72个头皮电极上记录AEP。相对于健康对照受试者，慢性和首发患者均显示出明显的N1振幅递减。至关重要的是，未受影响的一级亲戚也显示出明显的N1赤字。这项研究为精神分裂症的听觉N1缺陷与发展这种疾病的潜在遗传风险相关的提议提供了进一步的支持。根据最近的研究，这些结果表明N1缺陷是精神分裂症的一种内表型标记。讨论了该指标作为多元内表型元素之一的潜在未来实用性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号