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首页> 外文期刊>European Journal of Plastic Surgery >Application of regulated oxygen-enriched negative pressure-assisted wound therapy in combating anaerobic infections Oxygen-enriched negative pressure treatment
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Application of regulated oxygen-enriched negative pressure-assisted wound therapy in combating anaerobic infections Oxygen-enriched negative pressure treatment

机译：调节式富氧负压辅助伤口治疗在厌氧感染中的应用富氧负压治疗

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摘要

Regulated negative pressure-assisted wound therapy (RNPT) applies non-pharmaceutical technology for enhanced healing of hard to cure, acute and chronic wounds. Although used for over two decades, wound pO2 levels, an essential physical parameter inherent in RNPT that follows Henry’s Law of gases, have not been reported. Necrotizing fasciitis (NF), a severe soft tissue infection, necessitates prompt intensive therapeutic response using pharmaceutical, surgical, and hyperbaric oxygen treatment when anaerobes are involved. We report a linear decrease in pO2 values in direct correlation with sub-atmospheric pressure and concurrent changes in wound atmospheric pO2 by supplemented oxygen in an in vitro phantom leg simulated wound model treated with RNPT. We designed a system using regulated oxygen-enriched negative pressure therapy (RO-NPT) for controlling wound atmospheric pO2. A representative patient case report treated for NF with RO-NPT is presented. RNPT follows Henry’s law of gases and leads to a decrease in wound atmospheric pO2. The application of RNPT in anaerobic wound infections should be contraindicated. Wound pO2 is enhanced by simultaneous application of oxygen by RO-NPT. We have demonstrated the rationale for the possible use of RO-NPT for prevention of anaerobic wound infections and as a supplemental mode of treatment of NF.
机译：调节性负压辅助伤口疗法（RNPT）应用非药物技术来增强难以治愈的急性和慢性伤口的愈合。尽管使用了二十多年，伤口的pO 2 水平是RNPT固有的基本物理参数，遵循亨利气体定律，但尚无报道。坏死性筋膜炎（NF）是一种严重的软组织感染，当涉及到厌氧菌时，必须使用药物，手术和高压氧治疗迅速进行强烈的治疗反应。我们报告了在体外幻象腿模拟伤口中，pO 2 值的线性下降与低于大气压的压力以及伤口大气中的大气pO 2 的同时变化直接相关。 RNPT处理的模型。我们设计了一种使用调节型富氧负压疗法（RO-NPT）来控制伤口大气pO 2 的系统。提出了具有代表性的RO-NPT治疗NF患者案例。 RNPT遵循亨利气体定律，导致伤口的大气pO 2 降低。 RNPT在厌氧性伤口感染中的应用应禁忌。 RO-NPT同时施加氧气可增强伤口pO 2 。我们已经证明了RO-NPT可能用于预防厌氧伤口感染和作为NF治疗的补充方式的基本原理。

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