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MRI and 18FDG-PET in the assessment of bone marrow infiltration of the spine in cancer patients

机译：MRI和18 FDG-PET在评估癌症患者脊柱骨髓浸润中的作用

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摘要

The aim of this study was to evaluate the diagnostic value of MRI and 18FDG-PET in bone marrow infiltration of the spine due to metastases of solid tumours and lymphoma in cancer patients. In 35 cancer patients (solid tumours n = 26, lymphoma n = 9) MRI of the spine and 18FDG-PET were reviewed and the detectability of metastases, infiltration of the spine, extent of disease, and therapeutic implications were compared. In 8/35 cases (23%) imaging technique showed concordantly no bone marrow infiltration. In 19/35 patients (54%), both MRI and 18FDG-PET revealed bone marrow infiltration of the axial skeleton. In 12/19 patients (63%), MRI showed more extensive disease which lead to subsequent therapy. The imaging findings of MRI and 18FDG-PET were discordant in 8/35 cases (23%). 18FDG-PET was false positive in two patients. In six patients, 18FDG-PET failed to detect bone metastases and bone marrow infiltration of the spine, which was detected by MRI and proven by clinical follow-up with subsequent therapy in two cases. MRI is more sensitive and specific than 18FDG-PET detecting bone marrow metastases and infiltration of the spine and has a great impact in staging cancer patients.
机译：这项研究的目的是评估MRI和18 FDG-PET在癌症患者因实体瘤和淋巴瘤转移引起的脊柱骨髓浸润中的诊断价值。对35例癌症患者（实体瘤n = 26，淋巴瘤n = 9）进行了脊柱MRI检查和18 FDG-PET检查，并对转移灶的检测，脊柱浸润，疾病程度和治疗意义进行了分析。比较。在8/35例病例中（23％），影像学检查显示一致无骨髓浸润。 MRI和18 FDG-PET在19/35例患者（54％）中均显示出骨髓向轴骨架的浸润。在12/19例患者中（63％），MRI显示疾病更加广泛，导致随后的治疗。 MRI和18 FDG-PET的影像学表现在8/35例中不一致（23％）。 18例FDG-PET在两名患者中为假阳性。在6例患者中，有18枚FDG-PET未能检测到脊柱的骨转移和骨髓浸润，这在MRI中被检测到，并在随后的治疗中得到了临床随访证实，其中2例。 MRI比18 FDG-PET检测骨髓转移和脊柱浸润更为灵敏和特异，对癌症患者的分期具有重大影响。

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  • 来源
    《European Spine Journal》 |2007年第11期|1907-1912|共6页
  • 作者

    Nadir Alexander Ghanem; Gregor Pache; Christian Lohrmann; Ingo Brink; Thorsten Bley; Elmar Kotter; Thomas Kelly; Mathias Langer;

  • 作者单位

    Department of Diagnostic Radiology University Hospital Freiburg Hugstetter Strasse 55 79106 Freiburg Germany;

    Department of Diagnostic Radiology University Hospital Freiburg Hugstetter Strasse 55 79106 Freiburg Germany;

    Department of Diagnostic Radiology University Hospital Freiburg Hugstetter Strasse 55 79106 Freiburg Germany;

    Department of Nuclear Medicine University Hospital Freiburg Freiburg Germany;

    Department of Diagnostic Radiology University Hospital Freiburg Hugstetter Strasse 55 79106 Freiburg Germany;

    Department of Diagnostic Radiology University Hospital Freiburg Hugstetter Strasse 55 79106 Freiburg Germany;

    Department of Nuclear Medicine University Hospital Freiburg Freiburg Germany;

    Department of Diagnostic Radiology University Hospital Freiburg Hugstetter Strasse 55 79106 Freiburg Germany;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Bone marrow infiltration; Spine; Lymphoma; Solid tumour; MRI; 18FDG-PET;

    机译：骨髓浸润;脊柱;淋巴瘤;实体瘤;MRI;18FDG-PET;

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