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Hyperlipidemia In Rabbit Hemorrhagic Disease

机译:兔出血性疾病中的高脂血症

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Clinically healthy rabbits were inoculated with rabbit hemorrhagic disease virus (RHDV) and the kinetics of their serum lipid parameters and liver enzymes were monitored. After RHDV inoculation, hyperlipidemia was observed (P_(triglyceride)<0.0001, P_(cholesterol)=0.0003) along with significant increases in serum aspartate aminotransferase, alanine aminotransferase and γ-glutamyltransferase (P<0.0001). An exponential increase in serum triglyceride was also seen. Thus, the presence of hyperlipidemia (from 30 h post-inoculation) in the infected rabbits points to impairment in lipid metabolism. This is the first demonstration that RHDV infection leads to hyperlipidemia, probably due to the disorder of liver enzymes associated with lipid metabolism.
机译:对临床健康的兔接种兔出血性疾病病毒(RHDV),并监测其血脂参数和肝酶的动力学。 RHDV接种后,观察到高脂血症(P_(甘油三酸酯)<0.0001,P_(胆固醇)= 0.0003),同时血清天冬氨酸氨基转移酶,丙氨酸氨基转移酶和γ-谷氨酰转移酶显着增加(P <0.0001)。还发现血清甘油三酸酯呈指数增加。因此,在感染的兔子中存在高脂血症(从接种后30小时开始)表明脂质代谢受损。这是RHDV感染导致高脂血症的第一个证明,可能是由于与脂质代谢有关的肝酶失调。

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