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A plan of Japanese Mouse Clinic in RIKEN BRC

机译：RIKEN BRC日本小鼠诊所的计划

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In the ENU mutagenesis project, we have developed a systematic and comprehensive phenotyping, about 400 mutants have been generated, as a disease models for human diseases. Beside, we have developed a high-throughput gene mapping system and a database system of in silico exploration for candidates of mutant causative gene, in collaboration with Omic bioinformatics data integration team of RIKEN GSC. Using these systems, we successfully identified causative genes of 62 mutants. All information of most of mouse mutants we generated is now open to public through our home page. All these achievements are highly appreciated by international community. In the next stage we plan to reconstruct the existing phenotyping platform and to rebuild_a new platform. The new system has hierarchical structure, consisting of a basic pipeline that inherits the existing platform and the second pipeline, which is optimized for more in-depth phenotyping assays. Using this system, we will perform more comprehensive and profound phenotyping of mouse mutants as a Japanese Mouse Clinic, which are opened for Japanese science community. It is expected from the results of preceding foreign phenotyping projects that existing mouse mutants are revalued as new disease models by identified novel phenotypes. We also plan sharing of detailed information about standard operating procedures (SOP) of phenotyping analyses with other related large-scale projects, such as EUMODIC (European Mouse Disease Clinic) and MPP (Mouse Phenome Project), and annotation of mutant phenotypes with internationally standardized method, thereby we will contribute to international efforts for standardization of mouse phenotype data.
机译：在ENU诱变项目中，我们已经开发出系统且全面的表型分析方法，已经产生了约400个突变体，作为人类疾病的疾病模型。此外，我们还与RIKEN GSC的Omic生物信息学数据集成团队合作，开发了高通量基因作图系统和用于突变致病基因候选物的计算机在线探索数据库系统。使用这些系统，我们成功地鉴定了62个突变体的致病基因。我们生成的大多数小鼠突变体的所有信息现在都可以通过我们的主页公开。所有这些成就得到国际社会的高度赞赏。在下一阶段，我们计划重建现有的表型平台并重建一个新平台。新系统具有分层结构，由继承现有平台的基本管道和第二个管道组成，第二个管道针对更深入的表型分析进行了优化。使用此系统，我们将对作为日本小鼠诊所的小鼠突变体进行更全面，更深入的表型分析，并向日本科学界开放。从先前的外国表型计划的结果可以预期，现有的小鼠突变体将通过鉴定出的新表型被重新估价为新的疾病模型。我们还计划与其他相关的大型项目（例如EUMODIC（欧洲小鼠疾病诊所）和MPP（鼠标现象项目））共享有关表型分析标准操作程序（SOP）的详细信息，并注释具有国际标准化的突变表型因此，我们将为国际标准化小鼠表型数据的努力做出贡献。

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