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首页> 外文期刊>Experimental Animals >Studies on Development of Hairless Descendants of Mexican Hairless Dogs and Their Usefulness in Dermatological Science
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Studies on Development of Hairless Descendants of Mexican Hairless Dogs and Their Usefulness in Dermatological Science

机译：墨西哥无毛犬无毛后代的发育及其在皮肤科学中的应用研究

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In this study, we have established a colony of hairless descendants of MHDs. In addition, we clarified the dermatological characteristics of hairless dogs and their usefulness as a laboratory animals. This study can be summarized as follows. 1. An autosomal dominant monogenic gene (Hm; hairless, Mexican type) was responsible for the hairless characteristics of MHDs. 2. Red blood cell counts, hemoglobin concentrations, and packed cell volumes were slightly higher in hairless dogs than in Beagles. 3. The skin of hairless dogs clearly showed age-re- lated changes in the structure. 4. The epidermis of hairless dogs contained abundant melanocytes. Their skin clearly showed UV-induced changes such as sunburn and suntan reactions. 5. Sunscreens effectively protected the skin of hairless dogs from sunburn and suntan reactions induced by solar exposure. 6. Delayed type hypersensitivity reaction was weaker in hairless dogs than in Beagles. 7. Neonatal hairless pups developed hair growth reactions following minoxidil treatment only in the early period after birth. 8. The spotted pigmentation occurring on the skin of adult hairless dogs was depigmented by application of HQ. 9. Hairless dogs developed spontaneous comedones in the skin and the severity of these lesions subsided with the application of anti-acne agents. Hairless dogs are expected to be a useful model for the investigation of photodermatology, and the treatment of comedones, pigmentation and alopecia.
机译：在这项研究中，我们建立了MHD无毛后代的殖民地。此外，我们阐明了无毛犬的皮肤病学特征及其作为实验动物的有用性。这项研究可以总结如下。 1.常染色体显性单基因基因（Hm；无毛，墨西哥型）是MHDs无毛特征的原因。 2.无毛狗的红细胞计数，血红蛋白浓度和堆积细胞体积比Beagles略高。 3.无毛犬的皮肤明显显示出与年龄有关的结构变化。 4.无毛犬的表皮中含有丰富的黑素细胞。他们的皮肤清楚地显示出紫外线引起的变化，例如晒伤和晒黑反应。 5.防晒霜可有效保护无毛犬的皮肤免受日光照射引起的晒伤和晒黑反应。 6.迟发型超敏反应在无毛犬中比在小猎犬犬中弱。 7.新生无毛幼犬在米诺地尔治疗后才在出生后的早期出现毛发生长反应。 8.使用HQ可以去除成年无毛犬皮肤上的斑点色素沉着。 9.无毛犬皮肤上会形成自发粉刺，使用抗粉刺剂可缓解这些病变的严重程度。预计无毛狗将成为研究光皮肤病以及治疗粉刺，色素沉着和脱发的有用模型。

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