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首页> 外文期刊>Experimental Brain Research >Effects of cold stimulation on secondary hyperalgesia (HA) induced by capsaicin in healthy volunteers
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Effects of cold stimulation on secondary hyperalgesia (HA) induced by capsaicin in healthy volunteers

机译：冷刺激对辣椒素对健康志愿者继发性痛觉过敏的影响

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摘要

Little is known about the sensory characteristics and underlying mechanisms behind secondary hyperalgesia (HA) (2° HA). The aim of the present study was to investigate the relationships between two different noxious stimuli, mechanical and cold on capsaicin-induced 2° HA. Fourteen healthy volunteers were exposed to three different cold stimuli (20, 10, 0°C) 30 s each, on both forearms. The cold stimuli were applied before (baseline) and 8 min after intradermal administration of 50-μg capsaicin to the forearm, distally to the injection site in the inspected area of 2° HA. Pain intensities were assessed immediately after each cold stimulus by means of a visual analogue scale (cold-VAS). Additionally, areas of mechanical HA (cm2) were assessed distally and proximally to the injection site at three different time points: 5, 8 (right after the second series of cold stimuli), and 30 min after the injection. No significant differences in cold-VAS were found between pre- and post-capsaicin injection at the tested forearm (P= 0.334), whereas significant reduction from pre- to post-injection was found in cold-VAS in the control forearm (P= 0.024). Further, 8 min after the injection, the cold stimulation led to an expansion of 2° HA area (from 5.1±1.38 to 11.4±1.72 cm2) to punctuate stimuli distally but not proximally to the injection site (P<0.05). It is concluded that there is no HA to cold stimuli within the area of mechanical 2° HA. However, cooling acts as a conditioning stimulus and expands the area of capsaicin-induced punctuate HA.
机译：关于继发性痛觉过敏（HA）（2°HA）背后的感觉特征和潜在机制知之甚少。本研究的目的是研究辣椒素诱导的2°HA对两种不同的有害刺激，机械刺激和冷刺激之间的关系。 14名健康志愿者分别在两个前臂上分别接受三种不同的冷刺激（20、10、0°C）30 s。在（基线）之前和皮内注射50μg辣椒素至前臂，在2°HA检查区域的注射部位远端，施加冷刺激。在每次冷刺激后立即通过视觉模拟量表（冷-VAS）评估疼痛强度。此外，在三个不同的时间点，分别在注射部位的远端和近端评估机械性HA的面积（cm2 ）：5、8（第二次冷刺激后）和注射后30分钟。在经过测试的前臂中，辣椒素注射前和注射后之间，冷VAS没有发现显着差异（P = 0.334），而对照前臂的冷VAS从注射前到注射后均没有显着降低（P = 0.024）。此外，注射后8分钟，冷刺激导致2°HA面积扩大（从5.1±1.38到11.4±1.72 cm2 ），从而在注射部位的远端而不是近端刺破刺激物（P <0.05 ）。结论是在机械2°HA区域内没有HA刺激冷刺激。然而，冷却起到调节刺激的作用，并扩大了辣椒素诱导的点状HA的面积。

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