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首页> 外文期刊>Experimental Brain Research >Suppression of cutaneous reflexes by a conditioning pulse during human walking
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Suppression of cutaneous reflexes by a conditioning pulse during human walking

机译：在人类行走过程中通过调节脉冲抑制皮肤反射

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摘要

There are two ways in which responses to successive unexpected stimuli are attenuated, namely through habituation and conditioning. For the latter, it suffices that the unexpected stimulus is preceded by another just perceivable stimulus. In spinal cord reflexes this is termed conditioning, while in brainstem reflexes this is usually referred to as prepulse inhibition. Cutaneous reflexes in Tibialis Anterior (TA) are particularly strong during gait and they are thought to involve a transcortical loop. Can these reflexes be suppressed by giving a brief pulse prior to a reflex-evoking pulse given to the same nerve? To examine this question, electromyographic signals were recorded in healthy humans during walking. Sural nerve stimulation (train of five pulses (1 ms duration)) at 200 Hz were applied at two times perception threshold during different phases of the step cycle. The preceding pulse (single pulse of 1 ms at same intensity) was applied to the same nerve 150 ms before the reflex-evoking pulse train. Conditioning stimulation with a single pulse lowered significantly the following reflex response in the ipsilateral TA but much less in other muscles such as biceps femoris. The preceding pulse did not disturb the phase-dependent modulation or the typical reflex reversal. The finding that TA is selectively involved indicates that the suppressing mechanism may involve the motor cortex, which is known to be involved in the control of TA. The conditioning pulse did not cause a reduction in background activity. Therefore, the suppression of the reflex responses points to a premotoneuronal source such as presynaptic inhibition.
机译：有两种方法可以减弱对连续的意外刺激的响应，即通过适应和调节。对于后者，足够的是，在意外刺激之前是另一种可觉察的刺激。在脊髓反射中，这称为调节；而在脑干反射中，这通常称为前脉冲抑制。胫骨前部（TA）的皮肤反射在步态中特别强烈，并且认为它们涉及皮层上皮环。在向同一神经发出反射诱发脉冲之前，先给其短暂的脉冲，即可抑制这些反射吗？为了检查这个问题，在行走过程中在健康的人类中记录了肌电信号。在步幅周期的不同阶段，以两次感知阈值施加200 Hz的听神经刺激（五个脉冲（持续时间为1 ms））。在反射诱发脉冲序列之前150 ms，将前一个脉冲（相同强度的1 ms单个脉冲）施加到同一条神经。用单脉冲进行条件刺激会显着降低同侧TA的以下反射反应，而在其他肌肉（如股二头肌）中则要低得多。前一个脉冲不会干扰相位相关的调制或典型的反射反转。发现TA被选择性地参与的发现表明抑制机制可能与运动皮层有关，已知运动皮层与TA的控制有关。调节脉冲没有引起背景活性的降低。因此，反射反应的抑制指向诸如突触前抑制之类的运动前神经源。

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  • 来源
    《Experimental Brain Research》 |2006年第1期|67-76|共10页
  • 作者

    C. M. Bastiaanse; S. Degen; B. C. M. Baken; V. Dietz; J. Duysens;

  • 作者单位

    Department of Rehabilitation Medicine Radboud University Nijmegen Medical Center;

    Department of Rehabilitation Medicine Radboud University Nijmegen Medical Center;

    Department of Rehabilitation Medicine Radboud University Nijmegen Medical CenterSint Maartenkliniek SMK-research;

    Spinal Cord Injury Center University Hospital Balgrist;

    Department of Rehabilitation Medicine Radboud University Nijmegen Medical CenterSint Maartenkliniek SMK-research;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Tibialis Anterior; Conditioning stimulation; Sural nerve; Gait; Prepulse;

    机译：胫前肌;条件刺激;神经;步态;前冲;

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