Standardization of islet isolation outcome - A new automatic system to determine pancreatic islet viability

Giada La Scalia; Giuseppe Aiello; Cristiana Rastellini

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Standardization of islet isolation outcome - A new automatic system to determine pancreatic islet viability

机译：胰岛分离结果的标准化-一种确定胰岛生存力的新型自动系统

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Pancreatic islet transplantation is emerging as a therapeutic approach for patients affected by diabetes. This approach consists of a minimally invasive procedure replacing insulin-producing cells (pancreatic islets). The technique has been proven successful, but limitations have been identified. One of the major challenges of the procedure is the counting of the isolated pancreatic islets, which is currently jeopardized by subjectivity and inaccuracy. Determination of the accurate islet number is a crucial factor in determining the correlation between the isolation product and clinical outcome. In the proposed study, we have developed software capable of objectively evaluating islet numbers and other viability variables by image analysis. This software is based on image processing and feature extraction algorithms for recognition of the area of interest. This is the first step toward standardization of the isolation outcome and potential clinical success predictability.

机译：胰岛移植正在成为糖尿病患者的一种治疗方法。这种方法由微创手术替代胰岛素产生细胞（胰岛）组成。该技术已被证明是成功的，但是已经发现了局限性。该过程的主要挑战之一是对孤立的胰岛的计数，目前该胰岛的计数受到主观性和不准确性的影响。确定准确的胰岛数目是确定分离产物与临床结果之间相关性的关键因素。在拟议的研究中，我们开发了能够通过图像分析客观评估胰岛数目和其他生存力变量的软件。该软件基于图像处理和特征提取算法，用于识别感兴趣区域。这是标准化分离结果和潜在临床成功可预测性的第一步。

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来源
《Expert Systems with Application》 |2011年第4期|p.3461-3466|共6页
作者
Giada La Scalia; Giuseppe Aiello; Cristiana Rastellini;
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作者单位

University of Palermo, Department of Mechanical Technology, Production and Management Engineering, Palermo, Italy;

University of Palermo, Department of Mechanical Technology, Production and Management Engineering, Palermo, Italy;

University of Texas Medical Branch, Department of Surgery, Calveston, Texas, United States;

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正文语种 eng
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关键词
image analysis; feature extraction; pancreatic islets transplantation;

机译：图像分析;特征提取;胰岛移植;

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专利

1. Validation of the scoring system for standardization of the pancreatic donor for islet isolation as used in a new islet isolation center. [J] . Witkowski P, Liu Z, Cernea S, Transplantation Proceedings . 2006,第9期

机译：在新的胰岛分离中心中使用的胰岛分离标准化供体评分系统的验证。
2. The morphology of islets within the porcine donor pancreas determines the isolation result: successful isolation of pancreatic islets can now be achieved from young market pigs. [J] . Krickhahn M, Buhler C, Meyer T, Cell transplantation . 2002,第8期

机译：猪供体胰腺中胰岛的形态决定了分离结果：现在可以从市场上的仔猪中成功分离出胰岛。
3. Application of Digital Image Analysis to Determine Pancreatic Islet Mass and Purity in Clinical Islet Isolation and Transplantation [J] . Wang Ling-jia, Kissler Hermann J., Wang Xiaojun, Cell transplantation . 2015,第7期

机译：数字图像分析在临床胰岛分离和移植中确定胰岛质量和纯度的应用
4. MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability [C] . Colin Cook, Hirotake Komatsu, Mayra Salgado, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems amp; Eurosensors XXXIII . 2019

机译：MEMS硅片切割器，用于快速限制扩散胰岛的切片，以提高生存能力
5. Factors influencing the early results of pancreatic islet transplantation: Studies on isolation enzymes and islet revascularisation - Summary. [D] . Mathe, Zoltan. 2007

机译：影响胰岛移植早期结果的因素：分离酶和胰岛血运重建的研究-摘要。
6. Glutathione Ethyl Ester Supplementation during Pancreatic Islet Isolation Improves Viability and Transplant Outcomes in a Murine Marginal Islet Mass Model [O] . Alexandre S. Raposo do Amaral, Rena L. Pawlick, Erika Rodrigues, 2010

机译：胰岛分离过程中补充谷胱甘肽乙酯可提高小鼠边缘胰岛质量模型的生存能力和移植结果。
7. Glutathione ethyl ester supplementation during pancreatic islet isolation improves viability and transplant outcomes in a murine marginal islet mass model. [O] . Alexandre S Raposo do Amaral, Rena L Pawlick, Erika Rodrigues, 2013

机译：在胰岛分离过程中补充谷胱甘肽乙酯可改善小鼠边缘胰岛质量模型中的活力和移植结果。

Standardization of islet isolation outcome - A new automatic system to determine pancreatic islet viability

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