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首页> 外文期刊>Eye Science >Distribution of the Toxin following Medial Rectus Muscular Injection of Botulinum Toxin Gel in Rabbits
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Distribution of the Toxin following Medial Rectus Muscular Injection of Botulinum Toxin Gel in Rabbits

机译：内直肌肌肉注射肉毒杆菌毒素凝胶后兔体内毒素的分布

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Purpose: To determine the distribution of the toxin among individual muscles after intramuscular injection of botulinum toxin gel. Methods: One eye of 7 New Zealand white rabbits was randomized into group A, and the contralateral eye was into group B. Eyes in group A received medial rectus intramuscular injection of 2.5 IU of ~(125)I-BTX-A gel in 0.1ml, and those in group B received equivalent amount of ~(125)I-BTX-A solution by medial rectus intramuscular injection. Four rectus muscles and the levator palpebrae superioris were harvested and the radioactivity of muscles was measured 16 hours after the injection. Results: In group A, the radioactivity of per gram medial rectus was significantly higher than that of other muscles (P < 0.01), and there was no statistically significant difference in the radioactivity of per gram muscles among other muscles (P > 0.05). In group B, the radioactivity of per gram medial rectus and levator palpebrae superioris was significantly higher than that of other muscles respectively (P < 0.05), and the difference in the radioactivity of per gram muscles between medial rectus and levator palpebrae superioris was not statistically significant (P > 0.05). The radioactivity of per gram medial rectus in group A was higher than that in group B (t = 3.731, P = 0.01) , and there was no significant difference in the radioactivity of per gram muscles among other homonymous muscles (P > 0.05). Conclusion: The toxin dispersed principally in the injected muscle and the local concentration of the toxin was much high following intramuscular injection of botulinum toxin gel.
机译：目的：确定肌肉注射肉毒杆菌毒素凝胶后毒素在各个肌肉中的分布。方法：将7只新西兰大白兔的一只眼睛随机分为A组，对侧眼分为B组。A组的眼睛接受了腹直肌内侧肌肉注射0.1 IU的2.5IU〜（125）I-BTX-A凝胶。通过腹直肌内侧肌注，B组的患者接受了等量的〜（125）I-BTX-A溶液。注射后16小时，收集四只直肌和上睑提肌，并测量肌肉的放射性。结果：在A组中，每克内侧直肌的放射性显着高于其他肌肉（P <0.01），其他肌肉之间的每克肌肉的放射性没有统计学意义（P> 0.05）。 B组中，每克内侧直肌和上睑提肌的放射性分别显着高于其他肌肉（P <0.05），而在内侧直肌和上睑提肌之间每克肌肉的放射性差异无统计学意义。显着性（P> 0.05）。 A组每克内直肌的放射性高于B组（t = 3.731，P = 0.01），其他同义肌之间每克肌肉的放射性没有显着差异（P> 0.05）。结论：肌肉注射肉毒杆菌毒素凝胶后，毒素主要分散在注射的肌肉中，并且该毒素的局部浓度很高。

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