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Photodynamic Therapy for Age-related Macular Degeneration

机译：光动力疗法治疗老年性黄斑变性

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摘要

Purpose: To evaluate short-term effects of single photodynamic therapy (PDT) for age-related macular degeneration (AMD) accompanied with choroidal neovascularization (CNV). Methods: We analyzed retrospectively the effects of single PDT for 20 patients (20 eyes) with CNV caused by AMD. Corrected visual acuity, fluorescein angiography (FA) and optic coherence tomography (OCT) were examined before and after PDT. All patients were followed up at least 3 months. Results: At the end of 3-month follow-up, 5 eyes had vision progress, 15 eyes had vision stable and no eye had vision deterioration. Fluorescein angiography one week post PDT showed cessation of fluorescein leakage in 8 eyes with predominant classic CNV, and reduction of fluorescein leakage in 12 eyes with minimal classic CNV or occult CNV without classic component. At the 3-month following PDT fluorescein angiography showed fluorescein leakage reappeared in 4 of 8 eyes with predominant classic CNV. Among 12 eyes with minimal classic CNV or occult CNV without classic component, 9 eyes showed decreased or unchanged fluorescein leakage, 3 eyes had a progression of fluorescein leakage. Optic coherence tomography showed obvious recovery of serous sensory retinal detachment after PDT. Conclusion: PDT may occlude or inhibit CNV caused by AMD in short term. No obvious side effects were noticed.
机译：目的：评估单一光动力疗法（PDT）对年龄相关性黄斑变性（AMD）并伴有脉络膜新生血管（CNV）的近期效果。方法：我们回顾性分析了单次PDT治疗由AMD引起的20例（20眼）CNV的疗效。在PDT之前和之后检查校正后的视力，荧光素血管造影（FA）和光学相干断层扫描（OCT）。所有患者均接受了至少3个月的随访。结果：在3个月的随访结束时，有5只眼的视力进展，有15只眼的视力稳定，没有眼睛视力下降。 PDT一周后进行的荧光素血管造影显示，以经典经典CNV为主的8眼停止了荧光素的漏出，而具有最小经典CNV或隐匿性CNV且没有经典成分的12眼的荧光素漏出的减少。在PDT术后3个月，荧光血管造影显示8眼中有4眼以经典经典CNV为主，再次出现了荧光素渗漏。在具有最小经典CNV或隐匿性CNV且没有经典成分的12眼中，有9眼显示出荧光素渗漏减少或未改变，其中3眼有荧光素渗漏的进展。光学相干断层扫描显示PDT后浆液性视网膜视网膜脱离明显恢复。结论：PDT可在短期内阻塞或抑制AMD引起的CNV。没有发现明显的副作用。

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