• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Eye Science >Different Effects of Topical Prazosin and Pilocarpine on Uveoscleral Outflow in Rabbit Eyes
【24h】

Different Effects of Topical Prazosin and Pilocarpine on Uveoscleral Outflow in Rabbit Eyes

机译：局部吡唑嗪和毛果芸香碱对兔眼葡萄膜巩膜流出的不同影响

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: To investigate the effects of topical prazosin and pilocarpine on uveoscleral outflow(Fu) in rabbits. Methods: Sixteen rabbits were randomly divided into the control group (5 rabbits, only topical application of normal saline in the right eye of each rabbit), Prazosin (PZ) treated group (6 rabbits, only 0.1% Prazosin eyedrop 0.1% in the right eye of each one) and Pilocarpine (PC) treated group (5 rabbits, 1% Pilocarpine eye drop in each right eye). Intraocular pressure (IOP) of bilateral eyes of each rabbit was measured before and 1 h after topical application of the eye drop.And the bilateral eyes were perfused with Fluorescein-isothiocyanate bovine serum albumin (FITC-BSA) as the tracer into the anterior chamber of each rabbit for 30 min at 90 min after topical treatment. Then the rabbits were killed for Fu measurement. Results: IOP of PZ-treated eyes decreased [(0.71+-0.07)kPa] in 1 hour after PZ application. IOP of PC-treated eyes decreased [(0.70+-0.08)kPa] in 1 hour after PC application. The average value of Fu was (0.176+-0.048)μl/min in control eyes. The average value of Fu in PZ-treated eyes was (0.339+-0.018)μl/min. The average value of Fu in PC-treated eye was (0.123+-0.022)μl/min. Conclusion: Both of PZ and PC can decrease IOP in rabbits following topical application. Topical PZ can increase Fu in rabbits and this is one of the mechanisms of PZ-induced IOP decrease.Topical PC can prevent Fu. PC decreases IOP not through uveoscleral pathway. This study demonstrates that uveoscleral pathway plays an important role in aqueous humor drainage. PZ may be a novel drug for decreasing IOP. FITC-BSA is an effective tracer for studying uveoscleral pathway.
机译：目的：探讨局部应用哌唑嗪和毛果芸香碱对家兔眼葡萄膜巩膜外流的影响。方法：将16只兔随机分为对照组（5只兔，每只兔右眼仅局部应用生理盐水），Prazozin（PZ）治疗组（6只兔，仅0.1％Prazosin眼药水0.1％）每只眼睛一只）和毛果芸香碱（PC）治疗组（5只兔子，每只右眼含1％毛果芸香碱滴眼液）。在局部滴眼前后分别测量每只兔子的双眼眼压（IOP），并向双眼灌注前视荧光剂-异硫氰酸荧光素牛血清白蛋白（FITC-BSA）作为示踪剂在局部治疗后90分钟，每只兔子30分钟。然后杀死兔子以进行Fu测量。结果：PZ处理后的眼睛在1小时内的IOP降低了[（0.71 + -0.07）kPa]。施用PC后1小时，经PC治疗的眼睛的IOP降低了[（0.70 + -0.08）kPa]。对照眼中Fu的平均值为（0.176 + -0.048）μl/ min。经PZ处理的眼睛中Fu的平均值为（0.339 + -0.018）μl/ min。经PC处理的眼睛中Fu的平均值为（0.123 + -0.022）μl/ min。结论：局部应用PZ和PC均可降低家兔眼压。外用PZ可以增加家兔的Fu，这是PZ引起的IOP降低的机制之一。外用PC可以预防Fu。 PC不能通过葡萄膜巩膜途径降低IOP。这项研究表明葡萄膜巩膜通路在房水引流中起重要作用。 PZ可能是降低IOP的新型药物。 FITC-BSA是研究葡萄膜巩膜途径的有效示踪剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号