Species differences and effects of soft coral extracts from Sinnularia maximus on the expression of cytochrome P4501A and 2N in butterflyfishes (Chaetodon spp.)

B. C. DeBusk; M. Slattery; Jang-Seu Ki; Jae-Seong Lee; Rosaura Aparicio-Fabre; Daniel Schlenk

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Species differences and effects of soft coral extracts from Sinnularia maximus on the expression of cytochrome P4501A and 2N in butterflyfishes (Chaetodon spp.)

机译：中华大嘴Si（Sinnularia maximus）软珊瑚提取物的种类差异和对蝴蝶鱼中细胞色素P4501A和2N表达的影响（Chaetodon spp。）

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Cytochrome P450 (CYP) has been shown to confer resistance in numerous terrestrial insects that consume potentially toxic secondary metabolites in plants, but fewer studies have examined the role of critical biotransformation enzymes in allowing marine organisms to consume chemically defended foods. This study examined the expression of CYP1A and CYP2N mRNAs in several butterflyfish species, which can feed on numerous chemically defended soft and hard corals. In addition, the effect of an extract from a soft coral (Sinnularia maxima) on expression of hepatic CYP1A and CYP2 mRNAs was also examined. Fish were fed extracts on days 1, 3 and 5, and expression was examined on day 5. Phylogenetic analyses of the CYP1A cDNA from 12 species of butterflyfish (DNA, amino acid) indicate well-separated groupings according to their feeding strategies. The non-coralline feeding Chaetodon xanthurus exhibited a 7-fold higher basal expression of CYP2N8 relative to the other species studied. Although induction of CYP2N7 expression was observed in C. punctatofasciatus, CYP1A and CYP2N was largely unaffected or diminished by extract treatment in the other species of butterflyfish. These results indicated groupings of feeding strategy with CYP1A phylogeny in Chaetodon, but generally unaltered expression of CYP1A and CYP2N following dietary treatment with an extract from a chemically defended soft coral suggesting an inconclusive role of these isoforms in the detoxification of chemicals in these extracts.

机译：已证明细胞色素P450（CYP）在许多消耗植物中潜在有毒次生代谢产物的陆生昆虫中赋予抗性，但很少有研究研究关键生物转化酶在允许海洋生物消耗化学防御食品中的作用。这项研究检查了CYP1A和CYP2N mRNA在几种蝴蝶鱼中的表达，这些蝴蝶鱼可以以许多化学防御过的软珊瑚和硬珊瑚为食。此外，还研究了软珊瑚提取物（Sinnularia maxima）对肝CYP1A和CYP2 mRNA表达的影响。在第1、3和5天给鱼喂食提取物，并在第5天检查其表达。对12种蝴蝶鱼的CYP1A cDNA（DNA，氨基酸）进行系统进化分析，根据其喂食策略，它们可将各组分开。与研究的其他物种相比，以非珊瑚为食的Chaetodon xanthurus的CYP2N8基础表达高出7倍。尽管在点刺线虫中观察到了CYP2N7表达的诱导，但在其他蝴蝶鱼中，通过提取物处理后CYP1A和CYP2N基本上未受影响或减弱。这些结果表明在Chaetodon中以CYP1A系统发生的进食策略分组，但在用化学防御过的软珊瑚提取物饮食处理后，CYP1A和CYP2N的表达通常未改变，表明这些同工型在这些提取物中的化学物质解毒中起着不确定的作用。

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来源
《Fish Physiology and Biochemistry》 |2008年第4期|483-492|共10页
作者
B. C. DeBusk; M. Slattery; Jang-Seu Ki; Jae-Seong Lee; Rosaura Aparicio-Fabre; Daniel Schlenk;
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作者单位

Department of Biology Ouachita Baptist University Arkadelphia AR 71998 USA;

Department of Pharmacology School of Pharmacy University of Mississippi University MS 38677 USA;

Department of Chemistry College of Natural Sciences Hanyang University Seoul 133-791 South Korea;

Department of Chemistry College of Natural Sciences Hanyang University Seoul 133-791 South Korea;

Department of Environmental Sciences University of California Riverside Riverside CA 92521 USA;

Department of Environmental Sciences University of California Riverside Riverside CA 92521 USA;

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原文格式 PDF
正文语种 eng
中图分类
关键词
Cytochrome P450; Natural products; Coral reefs; Butterflyfish;

机译：细胞色素P450;天然产物;珊瑚礁;蝴蝶鱼;

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1. Species differences and effects of soft coral extracts from Sinnularia maximus on the expression of cytochrome P4501A and 2N in butterflyfishes (Chaetodon spp.) [J] . DeBusk B. C., Slattery M., Ki Jang-Seu, Fish Physiology and Biochemistry . 2008,第4期

机译：中华大嘴soft（Sinnularia maximus）软珊瑚提取物的种类差异及其对蝴蝶鱼细胞色素P4501A和2N表达的影响（Chaetodon spp。）
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Species differences and effects of soft coral extracts from Sinnularia maximus on the expression of cytochrome P4501A and 2N in butterflyfishes (Chaetodon spp.)

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