Ependymal cells of the mouse brain express urate transporter 1 (URAT1)

Naoko H Tomioka; Makiko Nakamura; Masaru Doshi; Yoshiharu Deguchi; Kimiyoshi Ichida; Takayuki Morisaki; Makoto Hosoyamada

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Ependymal cells of the mouse brain express urate transporter 1 (URAT1)

机译：小鼠大脑的室管膜细胞表达尿酸盐转运蛋白1（URAT1）

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Background Elevated uric acid (UA) is commonly associated with gout and it is also a known cardiovascular disease risk factor. In contrast to such deleterious effects, UA possesses neuroprotective properties in the brain and elucidating the molecular mechanisms involved may have significant value regarding the therapeutic treatment of neurodegenerative disease. However, it is not yet fully established how UA levels are regulated in the brain. In this study, we investigated the distribution of mouse urate transporter 1 (URAT1) in the brain. URAT1 is a major reabsorptive urate transporter predominantly found in the kidney.

机译：背景技术尿酸（UA）升高通常与痛风有关，也是已知的心血管疾病危险因素。与这种有害作用相反，UA在大脑中具有神经保护特性，阐明涉及的分子机制对于神经退行性疾病的治疗可能具有重要价值。但是，尚未完全确定如何在大脑中调节UA水平。在这项研究中，我们调查了小鼠尿酸盐转运蛋白1（URAT1）在大脑中的分布。 URAT1是主要在肾脏中发现的主要吸收性尿酸盐转运蛋白。

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《Fluids and Barriers of the CNS》 |2013年第1期|1-7|共7页
作者
Naoko H Tomioka; Makiko Nakamura; Masaru Doshi; Yoshiharu Deguchi; Kimiyoshi Ichida; Takayuki Morisaki; Makoto Hosoyamada;
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正文语种 eng
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Uric acid URAT1 Ependymal cells Cilia;

机译：尿酸URAT1表皮细胞纤毛;

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1. Ependymal cells of the mouse brain express urate transporter 1 (URAT1) [J] . Naoko H Tomioka, Makiko Nakamura, Masaru Doshi, Cerebrospinal Fluid Research . 2013,第1期

机译：小鼠大脑的室管膜细胞表达尿酸盐转运蛋白1（URAT1）
2. Ependymal cells of the mouse brain express urate transporter 1 (URAT1) [J] . Naoko H Tomioka, Makiko Nakamura, Masaru Doshi, Fluids and Barriers of the CNS . 2013,第2期

机译：小鼠大脑的室管膜细胞表达尿酸盐转运蛋白1（URAT1）
3. Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains [J] . Naoya Uemura, Ryuta Murakami, Yoichi Chiba, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2017,第期

机译：尿剂转运蛋白，Glut9和Urat1的免疫反应性位于人脑脉络膜丛的上皮细胞中
4. From Arginine to Greatine: Regional and Cellular Gene Expression of Enzymes and Transporters Linking Nitrogen and Energy Metabolism In Brain [C] . Claude Bachmann, Hugues Henry, Olivier Braissant Nestlé Nutrition Workshop . 2003

机译：从精氨酸到伟大：酶和转运蛋白的区域和细胞基因表达与脑中的氮气和能量代谢联系起来
5. Viral transfection of mesenchymal stem cells to overexpress brain-derived neurotrophic factor and nerve growth factor as potential therapies for reducing behavioral deficits in the YAC 128 mouse model of Huntington's disease. [D] . Dey, Nicholas D. 2009

机译：间充质干细胞的病毒转染以过度表达脑源性神经营养因子和神经生长因子，作为减少亨廷顿氏病YAC 128小鼠模型行为缺陷的潜在疗法。
6. Ependymal cells of the mouse brain express urate transporter 1 (URAT1) [O] . Naoko H Tomioka, Makiko Nakamura, Masaru Doshi, 2013

机译：小鼠大脑的室管膜细胞表达尿酸盐转运蛋白1（URAT1）
7. Ependymal cells of the mouse brain express urate transporter 1 (URAT1) [O] . 2013

机译：小鼠大脑的室管膜细胞表达尿酸盐转运蛋白1（URAT1）

Ependymal cells of the mouse brain express urate transporter 1 (URAT1)

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