...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta Alimentaria >INDUCTION OF SPECIFIC MUCOSAL IMMUNE RESPONSES BY VIABLE OR HEAT DENATURED PROBIOTIC BACTERIA OF LACTOBACILLUS STRAINS
【24h】

INDUCTION OF SPECIFIC MUCOSAL IMMUNE RESPONSES BY VIABLE OR HEAT DENATURED PROBIOTIC BACTERIA OF LACTOBACILLUS STRAINS

机译：活的或热变性的乳酸杆菌菌株对特定的粘膜免疫反应的诱导

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In recent years, research related to studying the effect of gut microflora on the human health has become of major economic importance. The main objective of our study was to examine whether or not the orally administered Lactobacillus strains (LB) as an oral adjuvant can improve the mucosal immune protection via an enhanced IgA secretion to a co-administered marker antigen ovalbumin (OVA). We adapted a murine (BALB/c) model to demonstrate beneficial adjuvant effects of probiotic LB strains. Orally sensitised mice with OVA. which were prefed with native or heat denatured (HD) Lactobacillus salivarius (Ls) or Lactobacillus casei (Lc) responded better or with the same efficiency to a vaccination with antigen (OVA) than mice that had been sensitised only with OVA or not sensitised at all. Antibody (IgA) responses in the gut were increased in response to vaccination with OVA in mice that had been prefed with native or heat denatured Ls or Lc followed by Ls or Lc and OVA feeding. In prefed groups, the OVA feeding alone primed for specific immune response, while adjuvanted OVA has increased the immune exclusion potential of the gut.
机译：近年来，与研究肠道菌群对人体健康的影响有关的研究已具有重要的经济意义。我们研究的主要目的是检查作为口服佐剂口服的乳杆菌菌株（LB）是否可以通过增强IgA对共同施用的标志物抗原卵清蛋白（OVA）的分泌来改善粘膜免疫保护。我们采用了鼠类（BALB / c）模型来证明益生菌LB菌株的有益佐剂作用。 OVA口服致敏小鼠。用天然或热变性（HD）唾液乳杆菌（Ls）或干酪乳杆菌（Lc）喂养的小鼠，对抗原（OVA）的疫苗接种的反应比仅对OVA致敏或对OVA不致敏的小鼠更好或更有效所有。预先接种天然或热变性的Ls或Lc，然后再接种Ls或Lc和OVA的小鼠，肠道中的抗体（IgA）反应会因接种OVA疫苗而增加。在预食组中，单独的OVA喂养可引发特定的免疫反应，而佐剂的OVA则增加了肠道的免疫排斥潜能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号