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首页> 外文期刊>Food additives & contaminantsu001fhpart Au001fiChemistry, analysis, control, exposure & risk assessment >Rapid multi-residue and multi-class qualitative screening for veterinary drugs in foods of animal origin by UHPLC-MS/MS
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Rapid multi-residue and multi-class qualitative screening for veterinary drugs in foods of animal origin by UHPLC-MS/MS

机译：通过UHPLC-MS / MS对动物源性食品中的兽药进行快速多残留和多类别定性筛选

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Multi-class UHPLC-MS/MS was developed for the analysis of more than 160 regulated or banned compounds of various classes: anthelmintics including benzimidazoles, avermectins and others; antibiotics including amphenicols, beta-lactams, macrolides, pyrimidines, quinolones, sulphonamides and tetracyclines; beta-agonists; corticosteroids; ionophores; nitroimidazoles; non-steroidal anti-inflammatory agents; steroids; and tranquillisers. Samples were extracted with acetonitrile, without any additional purification step, and analysed by using UHPLC-MS/MS. Validation was done in accordance with the guidelines laid down by European Commission Decision 2002/657/EC for qualitative screening methods. This simple method proved applicable to routine screening for residues in egg, honey, milk and muscle samples at half the maximum concentration permitted by the European Union for each drug. In most cases, the target value was set at 5μgkg~(-1) for unauthorised compounds.
机译：开发了多类UHPLC-MS / MS，用于分析160多种受管制或禁用的各种化合物：驱虫药，包括苯并咪唑，阿维菌素等；抗生素包括氨酚，β-内酰胺类，大环内酯类，嘧啶类，喹诺酮类，磺酰胺类和四环素类； β-激动剂；皮质类固醇;离子载体硝基咪唑;非甾体抗炎药；类固醇和镇定剂。样品用乙腈萃取，无需任何其他纯化步骤，然后使用UHPLC-MS / MS分析。根据欧洲委员会第2002/657 / EC号决定针对定性筛选方法制定的指南进行了验证。事实证明，这种简单方法适用于常规筛查鸡蛋，蜂蜜，牛奶和肌肉样品中的残留物，其残留量为欧盟允许的每种药物最大浓度的一半。在大多数情况下，将未经授权的化合物的目标值设置为5μgkg〜（-1）。

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