• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Food Chemistry >Mechanism of the effect of 2, 2′-azobis (2-amidinopropane) dihydrochloride simulated lipid oxidation on the IgG/IgE binding ability of ovalbumin
【24h】

Mechanism of the effect of 2, 2′-azobis (2-amidinopropane) dihydrochloride simulated lipid oxidation on the IgG/IgE binding ability of ovalbumin

机译：2,2'-偶氮二（2-脒基丙烷）二盐酸盐模拟脂质氧化对卵磷酸酯的IgG / IgE结合能力的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this work, the mechanism of the effect of lipid oxidation on the IgG/IgE binding ability of ovalbumin (OVA) was investigated via the peroxyl radicals produced by 2, 2'-azobis (2-amidinopropane) dihydrochloride to simulate lipid oxidation. Results showed that the structure of OVA unfolded partially with an increase in oxidation degree, leading to the exposure of the allergenic epitopes and increasing the IgG/IgE binding ability of OVA. Nine oxidation sites were found on the a-helix, and these sites may unwind the a-helix and expose the allergenic epitopes on the OVA surface, leading to antibody recognition and combination. Consequently, the IgG/IgE binding ability of OVA was increased. In conclusion, the allergenic capacity of OVA can be promoted by modifying peroxyl radical oxidation in processing egg products.
机译：在这项工作中，通过由2,2'-偶氮二苯胺（2-脒基丙烷）二盐酸盐产生的过氧基团来研究脂质氧化对卵蛋白（OVA）的IgG / IgE结合能力的影响的机制，以模拟脂氧化。结果表明，OVA的结构部分展开部分随着氧化程度的增加，导致过敏表位暴露并增加OVA的IgG / IgE结合能力。在A-Helix上发现九个氧化位点，这些位点可以放松α-螺旋并暴露OVA表面上的过敏表位，导致抗体识别和组合。因此，卵子的IgG / IgE结合能力增加。总之，通过在加工蛋产品中改性过氧基自由基氧化可以促进OVA的过敏能力。

著录项

  • 来源
    《Food Chemistry》 |2020年第15期|127037.1-127037.9|共9页
  • 作者

    Zhang Jing-jing; Tu Zong-cai; Wang Hui; Hu Yue-ming; Du Peng-cheng; Yang Yi-peng;

  • 作者单位

    Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China;

    Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China|Jiangxi Normal Univ Natl R&D Ctr Freshwater Fish Proc Nanchang 330022 Jiangxi Peoples R China|Jiangxi Normal Univ Engn Res Ctr Freshwater Fish High Value Utilizat Nanchang 330022 Jiangxi Peoples R China;

    Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China;

    Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China;

    Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China;

    Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Ovalbumin oxidation; Peroxyl radical; Lipids oxidation; IgG/IgE binding ability; Site identification;

    机译：卵蛋白氧化;过氧基自由基;脂质氧化;IgG / IgE结合能力;现场鉴定;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号