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首页> 外文期刊>Food Chemistry >Antihypertensive effect of mulberry leaf aqueous extract containing γ-aminobutyric acid in spontaneously hypertensive rats
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Antihypertensive effect of mulberry leaf aqueous extract containing γ-aminobutyric acid in spontaneously hypertensive rats

机译：含γ-氨基丁酸的桑叶水提取物对自发性高血压大鼠的降压作用

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摘要

We hypothesised that mulberry leaves (ML) exert their antihypertensive effect through y-aminobutyric acid (GABA) and that the antihypertensive activity of ML extract would be comparable to GABA alone in spontaneously hypertensive rats (SHR). We found that single administration of a water extract from leaves of Moms alba L. (WEML) lowered systolic blood pressure (SBP) transiently in a dose-dependent manner. Interestingly, the SBP-lowering effect of WEML was significantly higher than after treatment with GABA alone. We further found that WEML strongly inhibited angiotensin I-converting enzyme (ACE) activity in vitro with an IC_50 value of 29.8 mg/ml. These results suggest that WEML has a transient antihypertensive effect in vivo that may involve a mechanism of ACE inhibition in addition to GABA.
机译：我们假设桑叶（ML）通过γ-氨基丁酸（GABA）发挥其降压作用，并且自发性高血压大鼠（SHR）的ML提取物的降压活性与单独的GABA相当。我们发现，一次施用妈妈叶（WEML）叶片的水提取物可以剂量依赖性方式暂时降低收缩压（SBP）。有趣的是，WEML的SBP降低作用明显高于单独GABA治疗后。我们进一步发现，WEML在体外以29.8 mg / ml的IC_50值强烈抑制血管紧张素I转换酶（ACE）的活性。这些结果表明，WEML在体内具有短暂的降压作用，除了GABA以外，还可能涉及ACE抑制机制。

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  • 来源
    《Food Chemistry》 |2012年第4期|p.1796-1801|共6页
  • 作者

    Nae-Cherng Yang; Kun-Yan Jhou; Chin-Yin Tseng;

  • 作者单位

    School of Nutrition, Chung Shan Medical University, No. 110, Sec. 1,JianguoN. Rd., Taichung City 40201, Taiwan, ROC,Department of Nutrition, Chung Shan Medical University Hospital, No. 110, Sec. 1,Jianguo N. Rd., Taichung City 40201, Taiwan, ROC;

    Department of Food Science, National Chiayi University, No. 300, Syuefu Rd., Chiayi City 60004. Taiwan, ROC;

    Department of Nutrition and Health Science, Chung Chou Institute of Technology, No. 6, Lane 2, Sec. 3, Shan-Chiao Rd., Yuan-Lin, Changhua 510, Taiwan, ROC;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antihypertension; morus alba L; γ-aminobutyric acid; angiotensin I-converting enzyme; spontaneously hypertensive rat;

    机译：抗高血压桑rus γ-氨基丁酸;血管紧张素转换酶;自发性高血压大鼠;

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