2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: absorption and transport by human intestinal Caco-2 cells

T. Buhrke; F. Frenzel; J. Kuhlmann; A. Lampen

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2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: absorption and transport by human intestinal Caco-2 cells

机译：2-氯-1,3-丙二醇（2-MCPD）及其脂肪酸酯：人肠道Caco-2细胞的吸收和转运

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The heat-induced food contaminant 3-chloro-1,2-propanediol (3-MCPD) was recently classified as a possible human carcino-gen (category 2B) by the International Agency for Research on Cancer (IARC). The carcinogenic potential of the compound was demonstrated in several animal studies with kidney and testis being the primary target organs. On the basis of these data, a TDI value of 2 μg/kg bw/day was derived.

机译：国际癌症研究机构（IARC）最近将热诱导的食品污染物3-氯-1,2-丙二醇（3-MCPD）归类为可能的人类致癌物（类别2B）。该化合物的致癌潜力在多项动物研究中得到了证实，其中肾脏和睾丸是主要的靶器官。根据这些数据得出的TDI值为2μg/ kg bw /天。

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《Lebensmittelchemie》 |2016年第3期|51-51|共1页
作者
T. Buhrke; F. Frenzel; J. Kuhlmann; A. Lampen;
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Bundesinstitut für Risikobewertung (BfR), Abteilung Lebensmittelsicherheit, Berlin;

Bundesinstitut für Risikobewertung (BfR), Abteilung Lebensmittelsicherheit, Berlin;

Hamburg;

Bundesinstitut für Risikobewertung (BfR), Abteilung Lebensmittelsicherheit, Berlin;

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1. 2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: cytotoxicity, metabolism, and transport by human intestinal Caco-2 cells [J] . Buhrke Thorsten, Frenzel Falko, Kuhlmann Jan, Archives of Toxicology . 2015,第12期

机译：2-氯-1,3-丙二醇（2-MCPD）及其脂肪酸酯：人小肠Caco-2细胞的细胞毒性，代谢和转运
2. 2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: cytotoxicity, metabolism, and transport by human intestinal Caco-2 cells [J] . Buhrke Thorsten, Frenzel Falko, Kuhlmann Jan, Archives of Toxicology . 2015,第12期

机译：2-氯-1,3-丙二醇（2-MCPD）及其脂肪酸酯：人小肠Caco-2细胞的细胞毒性，代谢和转运
3. Absorption and metabolism of the food contaminant 3-chloro-1,2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells. [J] . Buhrke T, Weisshaar R, Lampen A Archives of Toxicology . 2011,第10期

机译：食物污染物3-氯-1,2-丙二醇（3-MCPD）及其脂肪酸酯被人肠道Caco-2细胞吸收和代谢。
4. Effect of medium chain fatty acids on cytoskeleton of human intestinal epithelial (CACO-2) cells [C] . Yukitaka Kimura, Masayo Yamaguchi, Motohiro Shima, Asia-Pacific biochemical engineering conference;APBIOCHEC'97 . 1997

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5. Role of peptide transporter PEPT1 in the intestinal absorption and pharmacokinetics of the amino acid ester prodrug valacyclover [D] . Yang, Bei 2012

机译：肽转运蛋白PEPT1在氨基酸酯前药valacyclover的肠道吸收和药代动力学中的作用
6. Biological Evaluation of Natural and Synthesized Homovanillic Acid Esters as Inhibitors of Intestinal Fatty Acid Uptake in Differentiated Caco-2 Cells [O] . Barbara Lieder, Joachim Hans, Fabia Hentschel, 2019

机译：天然和合成的高香草酸酯作为分化的Caco-2细胞中肠道脂肪酸摄取抑制剂的生物学评估
7. A Polymorphism in the Human Intestinal Fatty Acid Binding Protein Alters Fatty Acid Transport across Caco-2 Cells [O] . Leslie J. Baier, Clifton Bogardus, James C. Sacchettini 1996

机译：人肠脂肪酸结合蛋白中的多态性改变了Caco-2细胞的脂肪酸输送

2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: absorption and transport by human intestinal Caco-2 cells

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