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Influence of viscosity on the growth of human gut microbiota

机译：粘度对人体肠道菌群生长的影响

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Numerous studies support the beneficial effects of dietary fibre. It is well known that fibre increases viscosity at intestinal level. Therefore, the effects of fibre on gut microbiota could be due not only by its intestinal bacteria fermentation but also to the increase in viscosity by itself. The aim of this study was to evaluate the effect of viscosity on the growth of gut microbiota at physiological conditions. For this purpose, four compartments from a gastrointestinal simulator (simgi (R)) were filled with Gut Nutrient Medium (GNM) plus different agar concentrations (0, 0.30, 0.45 and 0.60%), inoculated with faecal microbiota, and incubated 48 h under anaerobic conditions. Samples were collected at three time points (0, 24 h and 48 h) for representative intestinal bacterial enumeration and rheological characterization. Incubation of GNM gels with faecal microbiota changed the medium viscosity over time, even with constant conditions (temperature and pH). In such way that, in absence of agar (low viscosity), viscosity slightly increased over time; however, in viscous mediums, viscosity decreased over time. In relation to the growth of gut microbiota, results showed that viscosity favoured the growth of total anaerobes and Clostridium spp.; in contrast, total number of aerobes and members of the genus Enterococcus correlated negatively with viscosity increment. In conclusion, changes in intestinal viscosity seem to selectively modify microbiota composition. This is a pioneer work to understand the effect of food viscosity in the gastrointestinal system, showing that viscosity is an important factor itself to condition the growth of different bacteria's groups. (C) 2017 Elsevier Ltd. All rights reserved.
机译：许多研究支持膳食纤维的有益作用。众所周知，纤维会增加肠道水平的粘度。因此，纤维对肠道菌群的影响不仅可以归因于其肠道细菌的发酵，还可以归因于其自身粘度的增加。这项研究的目的是评估在生理条件下粘度对肠道菌群生长的影响。为此，将来自胃肠道模拟器（simgi（R））的四个隔室充满肠道营养培养基（GNM）加不同浓度的琼脂（0、0.30、0.45和0.60％），接种粪便菌群，并在48 h下孵育48 h。厌氧条件。在三个时间点（0、24和48小时）收集样品，用于代表性的肠道细菌计数和流变学表征。即使在恒定的条件下（温度和pH值），GNM凝胶与粪便菌群的孵育也会随着时间的推移改变介质粘度。这样，在没有琼脂的情况下（低粘度），粘度会随时间而略有增加；但是，在粘性介质中，粘度会随时间下降。与肠道菌群的生长有关，结果表明，粘度有利于总厌氧菌和梭状芽胞杆菌的生长。相反，需氧菌和肠球菌属成员总数与粘度增加呈负相关。总之，肠道粘度的变化似乎选择性地改变了微生物群的组成。这是了解食物粘度在胃肠系统中作用的开创性工作，表明粘度本身是调节不同细菌族群生长的重要因素。 （C）2017 Elsevier Ltd.保留所有权利。

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