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Antimicrobial resistance and its association with tolerance to heavy metals in agriculture production

机译:抗菌素耐药性及其与农业生产中对重金属的耐受性

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摘要

Antimicrobial resistance is a recognized public health challenge that since its emergence limits the therapeutic options available to veterinarians and clinicians alike, when treatment is warranted. This development is further compounded by the paucity of new antibiotics. The agri-food industry benefits from the availability of antimicrobial compounds for food-animal production and crop protection. Nonetheless, their improper use can result in the selection for bacteria that are phenotypically resistant to these compounds. Another class of agents used in agriculture includes various cationic metals that can be included in animal diets as nutritional supplements or spread on pastures to support crop growth and protection. Heavy metals, in particular, are giving rise to concerns among public health professionals, as they can persist in the environment remaining stable for prolonged periods. Moreover, bacteria can also exhibit resistance to these chemical elements and the genes encoding this phenotype can be physically localized to plasmids that may also contain one or more antimicrobial resistance-encoding gene(s). This paper reviews our current understanding of the role that bacteria play in expressing resistance to heavy metals. It will describe how heavy metals are used in agri-food production, and explore evidence available to link resistance to heavy metals and antimicrobial compounds. In addition, possible solutions to reduce the impact of heavy metal resistance are also discussed, including using organic minerals and reducing the level of trace minerals in animal feed rations.
机译:抗菌素耐药性是公认的公共卫生挑战,因为它的出现限制了在需要治疗时兽医和临床医生等可获得的治疗选择。新抗生素的匮乏进一步加剧了这一发展。农业食品工业得益于可用于食品动物生产和作物保护的抗菌化合物。但是,如果使用不当,可能会导致选择对这些化合物具有表型抵抗力的细菌。农业中使用的另一类试剂包括各种阳离子金属,这些阳离子金属可以作为营养补品或在牧场上铺展,以支持作物生长和保护,包括在动物饮食中。特别是重金属,由于它们可以在环境中长期保持稳定,因此引起了公共卫生专业人员的关注。而且,细菌还可以表现出对这些化学元素的抗性,并且编码该表型的基因可以物理地定位于质粒,所述质粒也可以包含一个或多个抗微生物性编码基因。本文回顾了我们目前对细菌在表达对重金属的抗性中所起的作用的理解。它将描述如何在农业食品生产中使用重金属,并探索将抗性与重金属和抗菌化合物联系起来的现有证据。此外,还讨论了减少重金属抗性影响的可能解决方案,包括使用有机矿物质和减少动物饲料中微量矿物质的含量。

著录项

  • 来源
    《Food microbiology》 |2017年第6期|23-32|共10页
  • 作者单位

    UCD-Centre for Food Safety, School of Public Health, Physiotherapy & Sports Science, University College Dublin, Belfield, Dublin D04 N2E5, Ireland;

    UCD-Centre for Food Safety, School of Public Health, Physiotherapy & Sports Science, University College Dublin, Belfield, Dublin D04 N2E5, Ireland;

    UCD-Centre for Food Safety, School of Public Health, Physiotherapy & Sports Science, University College Dublin, Belfield, Dublin D04 N2E5, Ireland;

    UCD-Centre for Food Safety, School of Public Health, Physiotherapy and Sports Science, UCD-Centre for Molecular Innovation & Drug Discovery, [room S1.05], University College Dublin, Belfield, Dublin D04 N2E5, Ireland;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Antibiotic resistance; Co-selection; Organic minerals; Metal tolerance;

    机译:抗生素耐药性;共选;有机矿物质;金属公差;

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