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首页> 外文期刊>Food research international >Antidiabetic effect of konjac glucomannan via insulin signaling pathway regulation in high-fat diet and streptozotocin-induced diabetic rats
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Antidiabetic effect of konjac glucomannan via insulin signaling pathway regulation in high-fat diet and streptozotocin-induced diabetic rats

机译：Konjac Glucomannan在高脂饮食中胰岛素信号通路调控的抗糖尿病作用及链脲佐菌素诱导的糖尿病大鼠

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摘要

Type 2 diabetes mellitus is a chronic metabolic disorder that tends to disarray various metabolic pathways. Dietary-mediated T2DM prevention garners much attention in recent decades. Hence, this study was intended to elucidate the antidiabetic properties of Konjac glucomannan (KGM) in diabetic rats. Our experimental design includes five groups, with six rats in each group. Group 1 feeding standard diet pallet alone served as control rats; group 2 was KGM control rats administered intragastrically with KGM (120 mg/kg b.w.). Group 3 was developed as diabetic rats with a high-fat diet and an intraperitoneal injection of Streptozotocin-40 mg/kg b.w. Group 4 were diabetic rats treated with KGM (80 mg/kg b.w.), and group 5 were diabetic rats received rosiglitazone treatment (4 mg/kg b.w.). The results showed that STZ-induced diabetic rats significantly elevate liver marker enzymes and gluconeogenesis enzymes. Diminished glycolytic enzymes, liver glycogen, insulin signaling genes, and proteins were also seen in diabetic rats. Treatment with KGM augmented glycolytic enzymes and liver glycogen. On the other hand, KGM diminished gluconeogenesis, liver marker enzymes, upregulated gene, and protein expression of the insulin pathway. The current results suggest dietary KGM can offer a better health benefit in the treatment of T2DM.
机译：2型糖尿病是一种慢性代谢紊乱，往往会混乱各种代谢途径。近几十年来，膳食介导的T2DM预防合作伙伴关注。因此，本研究旨在阐明糖尿病大鼠Konjac Glucomanannan（KGM）的抗糖尿病性质。我们的实验设计包括五组，每组六只大鼠。 1组喂养标准饮食托盘单独用作对照大鼠;第2组是KGM对照大鼠用KGM（120mg / kg B.）施用胃内施用。第3组作为糖尿病大鼠开发，具有高脂饮食和腹腔内注射链脲佐菌素-40mg / kg B.W.第4组是用KGM（80mg / kg B.）处理的糖尿病大鼠，第5组是糖尿病大鼠接受Rosiglitazone治疗（4mg / kg B.W.）。结果表明，STZ诱导的糖尿病大鼠显着提高肝脏标记酶和葡糖生成酶。在糖尿病大鼠中也观察到糖酵解酶，肝糖原，胰岛素信号传导基因和蛋白质减少。用KGM增强糖酵解酶和肝糖原处理。另一方面，KGM减少了葡糖苷，肝脏标记酶，上调基因和胰岛素途径的蛋白质表达。目前的结果表明膳食KGM可以在治疗T2DM时提供更好的健康益处。

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  • 来源
    《Food research international》 |2021年第11期|110664.1-110664.9|共9页
  • 作者

    Li Xunhan; Jayachandran Muthukumaran; Xu Baojun;

  • 作者单位

    BNU HKBU United Int Coll Food Sci & Technol Program 2000 Jintong Rd Zhuhai 519087 Guangdong Peoples R China;

    BNU HKBU United Int Coll Food Sci & Technol Program 2000 Jintong Rd Zhuhai 519087 Guangdong Peoples R China|Tongji Univ Shanghai Peoples Hosp 10 Sch Med Dept Endocrinol & Metab Shanghai 200072 Peoples R China;

    BNU HKBU United Int Coll Food Sci & Technol Program 2000 Jintong Rd Zhuhai 519087 Guangdong Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Konjac glucomannan; Type-2 diabetes mellitus; High fat diet; Streptozotocin; Insulin signaling pathway;

    机译：Konjac Glucomannan;2型糖尿病;高脂饮食;链脲佐菌素;胰岛素信号通路;

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