Flaniostatin, a new isoflavonoid glycoside isolated from the leaves of Cudrania tricuspidata as a tyrosinase inhibitor

Youngkyoung Kang; Jeong-Un Choi; Eun-Ah Lee; Hae-Ryong Park

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Flaniostatin, a new isoflavonoid glycoside isolated from the leaves of Cudrania tricuspidata as a tyrosinase inhibitor

机译：Flaniostatin，一种新的异黄酮苷，从Cudrania tricuspidata的叶子中分离出，作为酪氨酸酶抑制剂

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In the course of screening program for skin whitening compounds, flaniostatin (FST) was isolated from the leaves of Cudrania tricuspidata as a novel inhibitor of tyrosinase. The structure of FST was determined by ESI-MS and NMR spectroscopic analyses as a new isoflavone glycoside. The FST was exhibited a tyrosinase inhibitory effect in a dose-dependent manner. This effect was higher than that of arbutin at the same concentrations. These results indicated that FST isolated from C. tricuspidata may be a positive tool for skin-whitening agent research.

机译：在皮肤增白化合物的筛选程序中，从Cu草的叶子中分离出了氟尼他汀（FST）作为酪氨酸酶的新型抑制剂。 FST的结构通过ESI-MS和NMR光谱分析确定为新的异黄酮糖苷。 FST以剂量依赖的方式表现出酪氨酸酶抑制作用。在相同浓度下，该效果高于熊果苷。这些结果表明，从C. tricuspidata分离的FST可能是皮肤增白剂研究的积极工具。

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《Food Science and Biotechnology》 |2013年第5期|1-4|共4页
作者
Youngkyoung Kang; Jeong-Un Choi; Eun-Ah Lee; Hae-Ryong Park;
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作者单位

Department of Food Science and Biotechnology Kyungnam University">(1);

Department of Food Science and Biotechnology Kyungnam University">(1);

Department of Food Science and Biotechnology Kyungnam University">(1);

Department of Food Science and Biotechnology Kyungnam University">(1);

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正文语种 eng
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关键词
tyrosinase; Cudrania tricuspidata; isoflavonoid glycoside; flaniostatin;

机译：酪氨酸酶;dra木;异黄酮苷;黄素抑制素;

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机译：从Cudrania Tricuspidata的叶子中分离的Kaempferol 7-O-SS-D-葡萄糖苷通过在Raw 264.7巨噬细胞的NF-Kappa B，AP-1和Jak-Stat的灭活来抑制LPS诱导的促炎介质表达
2. Isolation of Prenylated Isoflavonoids from Cudrania tricuspidata Fruits that Inhibit A2E Photooxidation [J] . Golam Mezbah Uddin, Hee Ju Lee, Je Seung Jeon, Natural product sciences . 2011,第3期

机译：Cu草果实中抑制A2E光氧化作用的烯丙基异黄酮类化合物的分离
3. Characterization of tyrosinase inhibitors in the twigs of Cudrania tricuspidata and their structure-activity relationship study. [J] . Zheng ZongPing, Tan HuiYuan, Chen Jie, Fitoterapia . 2013,第Null期

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4. Docking Interaction Study on Commercial Tyrosinase Inhibitors and Tyrosinase [C] . Xueke Liu, Yan Xu, Yun Ling, Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization . 2012

机译：商业酪氨酸酶抑制剂与酪氨酸酶的对接相互作用研究
5. Extraction and Quantification of Cardiac Glycosides from Asclepias viridis Leaves [D] . George, Gary. 2020

机译：Asclepias Viridis叶片中心糖苷的提取和定量
6. A Prenylated Xanthone Cudratricusxanthone A Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia [O] . Chi-Su Yoon, Dong-Cheol Kim, Tran Hong Quang, 2016

机译：从Cu草中分离出的异戊烯酮黄Cu酮A通过抑制BV2小胶质细胞中的NF-κB和p38 MAPK途径抑制脂多糖诱导的神经炎症。
7. A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia [O] . Chi-Su Yoon, Dong-Cheol Kim, Tran Hong Quang, 2016

机译：从Cudrania tricuspidata分离的异戊烯化Xanthone，Cudratricusxanthone a通过抑制BV2小胶质细胞中的NF-κB和p38 mapK途径抑制脂多糖诱导的神经炎症

Flaniostatin, a new isoflavonoid glycoside isolated from the leaves of Cudrania tricuspidata as a tyrosinase inhibitor

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