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首页> 外文期刊>Food Science and Biotechnology >Anti-obesity effect of komulkosiraegi [Gracilaria vermiculophylla (Ohmi) Papenfuss] extract in 3T3-L1 cells
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Anti-obesity effect of komulkosiraegi [Gracilaria vermiculophylla (Ohmi) Papenfuss] extract in 3T3-L1 cells

机译：mul草（Gracilaria vermiculophylla（Ohmi）Papenfuss）提取物在3T3-L1细胞中的抗肥胖作用

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摘要

The ingestion of edible seaweed has long been believed to be beneficial to human health due to its numerous biological actions. In the present study, the ethyl acetate fraction of a komulkosiraegi [Gracilaria vermiculophylla (Ohmi) Papenfuss] ethanol extract (GEFr) was found to potently inhibit adipogenesis of 3T3-L1 preadipocytes, decreasing triglycerol accumulation and the expression of peroxisome proliferator-activated receptor γ (PPARγ), members of the CCAAT/enhancer-binding protein (C/EBP) family, and fatty acid binding protein 2 (aP2). In mature adipocytes, GEFr was found to significantly activate AMP-activated protein kinase (AMPK) by activating liver kinase B1 (LKB1) and stimulating intracellular reactive oxygen species generation. The mRNA levels of genes involved in lipid catabolism were up-regulated. Also, GEFr increased lipolysis in a dose-dependent manner. Taken together, these results suggest that GEFr has potential for use in therapies designed to improve obesity.
机译：长期以来，食用海藻由于其多种生物学作用，被认为对人体健康有益。在本研究中，发现Komulkosiraegi [Gracilaria vermiculophylla（Ohmi）Papenfuss]乙醇提取物（GEFr）的乙酸乙酯级分有效抑制3T3-L1前脂肪细胞的脂肪生成，降低甘油三酸酯的积累和过氧化物酶体增殖物激活的受体γ的表达。 （PPARγ），CCAAT /增强子结合蛋白（C / EBP）家族的成员和脂肪酸结合蛋白2（aP2）。在成熟的脂肪细胞中，发现GEFr通过激活肝激酶B1（LKB1）并刺激细胞内活性氧的生成来显着激活AMP激活的蛋白激酶（AMPK）。参与脂质分解代谢的基因的mRNA水平上调。同样，GEFr以剂量依赖性方式增加脂解作用。综上所述，这些结果表明，GEFr在设计用于改善肥胖症的疗法中具有潜力。

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  • 来源
    《Food Science and Biotechnology》 |2012年第1期|p.83-89|共7页
  • 作者

    Hyo-Min Kim; Seong-Il Kang; Hye-Sun Shin; Hee-Chul Ko; Youn-Suk Hong; Seung-Woo Kang; Sun-A Yoon; Jeong-Hwan Kim; Se-Jae Kim;

  • 作者单位

    Department of Biology and Research Institute for Basic Science, Jeju National University, Jeju, 690-756, Korea;

    Department of Biology and Research Institute for Basic Science, Jeju National University, Jeju, 690-756, Korea;

    Department of Biology and Research Institute for Basic Science, Jeju National University, Jeju, 690-756, Korea;

    Jeju Sasa Industry Development Agency, Jeju National University, Jeju, 690-756, Korea;

    Department of Biology and Research Institute for Basic Science, Jeju National University, Jeju, 690-756, Korea;

    Department of Biology and Research Institute for Basic Science, Jeju National University, Jeju, 690-756, Korea;

    Department of Biology and Research Institute for Basic Science, Jeju National University, Jeju, 690-756, Korea;

    Department of Biology and Research Institute for Basic Science, Jeju National University, Jeju, 690-756, Korea;

    Department of Biology and Researc;

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  • 正文语种 eng
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  • 关键词

    AMP-activated protein kinase; anti-adipogenic effect; Gracilaria vermiculophylla; 3T3-L1 cell;

    机译：AMP激活的蛋白激酶;抗脂肪形成作用;Gra草;3T3-L1细胞;

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