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首页> 外文期刊>Food Science and Biotechnology >Ameliorative effect of saltwort (Salicornia herbacea) extract on hepatic dysfunction and hyperlipidemia in rats
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Ameliorative effect of saltwort (Salicornia herbacea) extract on hepatic dysfunction and hyperlipidemia in rats

机译：咸草提取物对大鼠肝功能异常和高脂血症的改善作用

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摘要

To examine the effect of saltwort (Salicornia herbacea) on blood cholesterol and lipid metabolism, hyperlipidemia was induced in animal rats. Saltwort extract was then administered to the rats for 5 weeks, after which, blood biochemical changes were determined. Saltwort treatment resulted in a significant reduction of the levels of total cholesterol, blood triglyceride, and LDL-cholesterol. In contrast, the expression levels of HDL-cholesterol were increased at saltwort treatment group. The aspartate aminotransferase (AST: serum SGOT) value of the saltwort administration group was significantly reduced and the blood alanine aminotransferase (ALT: serum SGPT) levels decreased significantly in comparison to those in the negative control group. Degeneration of hepatic tissues due to the consumption of a high lipid diet for a long period of time was reported in the negative control group. On the other hand, in the saltwort administration group, a substantial reduction in the accumulation of lipid droplets in the cytoplasm was seen, and in addition, it was confirmed that the degeneration of hepatic tissues recovered almost to level of that of the normal control group. These data suggest that saltwort extract represents an excellent candidate for protection of rat hepatocytes from high fat diet-mediated damage.
机译：为了检查盐草（Salicornia herbacea）对血液胆固醇和脂质代谢的影响，在动物大鼠中诱导了高脂血症。然后将鼠尾草提取物施用于大鼠5周，然后测定血液生化变化。 Saltwort治疗导致总胆固醇，血液甘油三酸酯和LDL-胆固醇水平显着降低。相反，盐草治疗组HDL-胆固醇的表达水平升高。与阴性对照组相比，盐草给药组的天冬氨酸转氨酶（AST：血清SGOT）值显着降低，血液丙氨酸转氨酶（ALT：血清SGPT）水平显着降低。阴性对照组报告由于长期食用高脂饮食而导致肝组织变性。另一方面，在Saltwort给药组中，可以看到脂质滴在细胞质中的积聚大大减少，此外，可以确认肝组织的变性几乎恢复到正常对照组的水平。 。这些数据表明，紫苏提取物是保护大鼠肝细胞免受高脂饮食介导的损伤的极佳候选者。

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