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首页> 外文期刊>Food Science and Biotechnology >Anti-proliferative properties of ethyl acetate extract of Phellinus linteus grown on ginseng (Panax ginseng) on HT-29 human colon carcinoma cells through inducing apoptosis
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Anti-proliferative properties of ethyl acetate extract of Phellinus linteus grown on ginseng (Panax ginseng) on HT-29 human colon carcinoma cells through inducing apoptosis

机译：人参（Panax ginseng）生长的人参桑树乙酸乙酯提取物通过诱导细胞凋亡抑制HT-29人结肠癌细胞的增殖

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摘要

Phellinus linteus (PL) and ginseng (Panax ginseng, PG) have been widely used as traditional herbal medicines in East Asia. In this study, we evaluated whether the extract of P. linteus grown on ginseng (PGP) exhibited an more enhanced anti-proliferative activity on HT-29 human colon carcinoma cells than PL or PG extract. PGP EtOAc extract inhibited HT-29 cancer cell viability stronger than PG or PL EtOAc extract. FACS analysis revealed that PGP EtOAc extract increased sub-G1 (apoptotic) HT-29 cell population. The nuclear structures of HT-29 cells were disrupted, resulting in apoptotic fragments (45 kDa) of lamin B after treating PGP EtOAc extract. PGP EtOAc extract induced activation of caspase-8 and -9 in HT-29 cells. These results suggest that the PGP EtOAc extract has a direct anti-cancer effect through apoptosis and cell cycle blockade in HT-29 human colon carcinoma cells.
机译：桑黄（PL）和人参（Panax ginseng，PG）在东亚已被广泛用作传统草药。在这项研究中，我们评估了人参（PGP）上生长的桔梗提取物是否对PL-PG或HT-29人结肠癌细胞具有更强的抗增殖活性。 PGP EtOAc提取物比PG或PL EtOAc提取物更能抑制HT-29癌细胞的活力。 FACS分析表明PGP EtOAc提取物增加了sub-G1（凋亡）HT-29细胞的数量。处理PGP EtOAc提取物后，HT-29细胞的核结构被破坏，导致层粘连蛋白B的凋亡片段（45 kDa）。 PGP EtOAc提取物诱导HT-29细胞中caspase-8和-9的活化。这些结果表明，PGP EtOAc提取物通过HT-29人结肠癌细胞的凋亡和细胞周期阻滞具有直接的抗癌作用。

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