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首页> 外文期刊>Food Science and Biotechnology >Inhibitory effect of sowthistle (Ixeris dentata) on development and expression of behavioral locomotor sensitization to nicotine in rats
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Inhibitory effect of sowthistle (Ixeris dentata) on development and expression of behavioral locomotor sensitization to nicotine in rats

机译：苦w对大鼠尼古丁行为运动敏化的发展和表达的抑制作用

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摘要

The aim of this study was to investigate the effects of sowthistle (Ixeris dentata, IXD) on development and expression of nicotine-induced locomotor sensitization and underlying neuronal activation reflected by c-Fos expression in rats. Rats were pretreated with IXD 30 min before a daily injection of nicotine during an 8-day development phase and then challenged with nicotine after a 6-day withdrawal period. In another set of experiments, same IXD doses were administered once 30 min before nicotine challenge. Daily IXD treatment during development phase was not effective in blocking nicotine-induced locomotor sensitization in rats. However, a single IXD treatment after the development and withdrawal periods of nicotine sensitization significantly alleviated sensitized locomotor behavior on day 15. These behavioral results were coincident with significant inhibition of nicotineinduced c-Fos expression in the nucleus accumbens. These results indicated that IXD pretreatment significantly blocked the expression, but not the development of nicotine-induced locomotor sensitization in rats.
机译：这项研究的目的是调查so粉对大鼠尼古丁诱导的运动敏化和由c-Fos表达反映的潜在神经元活化的发育和表达的影响。在8天的发育阶段每天注射尼古丁之前30分钟用IXD预处理大鼠，然后在停药6天后用尼古丁攻击。在另一组实验中，在尼古丁激发前30分钟，一次给予相同的IXD剂量。在发育阶段每日进行IXD治疗并不能有效地阻止尼古丁引起的大鼠运动敏化。然而，在尼古丁致敏作用的发展和停药期后的第一个IXD治疗在第15天显着减轻了敏锐的运动行为。这些行为结果与尼古丁诱导伏隔核中c-Fos表达的显着抑制相吻合。这些结果表明，IXD预处理显着阻断了大鼠的表达，但未阻断尼古丁引起的运动敏化。

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  • 来源
    《Food Science and Biotechnology》 |2012年第3期|p.723-729|共7页
  • 作者

    Bombi Lee; Jinhee Park; Sunoh Kwon; Mijung Yeom; Bongjun Sur; Insop Shim; Hyejung Lee; Suk Hoo Yoon; Dong-Myong Jeong; Dae-Hyun Hahm;

  • 作者单位

    Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Korea;

    Graduate School of Basic Science of Oriental Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Korea;

    Graduate School of Basic Science of Oriental Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Korea;

    Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Korea;

    Graduate School of Basic Science of Oriental Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Korea;

    Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Korea;

    Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Korea;

    Division of I;

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  • 正文语种 eng
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  • 关键词

    sowthistle (Ixeris dentata); nicotine; locomotor sensitization; c-Fos;

    机译：w;尼古丁;运动敏化;c-Fos;

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