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首页> 外文期刊>Food Science and Biotechnology >Hyperglycemic effect of submerged culture extract of Ceriporia lacerata in streptozotocin-induced diabetic rats
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Hyperglycemic effect of submerged culture extract of Ceriporia lacerata in streptozotocin-induced diabetic rats

机译：蜡状孢子藻深层培养提取物对链脲佐菌素诱导的糖尿病大鼠的降血糖作用

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摘要

The hypoglycemic effects of Ceriporia lacerata (CL) extracts and mycelium were investigated in vitro and in vivo. The culture broth of CL was extracted with water and 70% ethanol. CL extracts exhibited high inhibitory activities against α-amylase and α-glucosidase. In the oral glucose tolerance test with CL extract and mycelium, glucose level reduction was 25.58 and 24.41%, respectively after 60 min of glucose feeding compared with the glucose groups. Male SD rats were divided into normal control (NC), STZ-induced diabetic group (DM), STZ plus CL extracts treated group (DM-E), and STZ plus mycelium treated group (DM-M). The supplementation of CL extracts and mycelium suppressed plasma glucose and lipid levels compared with the DM group. In addition, the alanine aminotransferase (ALT) and aspartate transaminase (AST) levels of the DM-E group were also decreased with values of 62.08 and 59.83 IU/mL, respectively compared to the DM group. Therefore, it is suggested that the extract and mycelium of CL alleviates the diabetic complications.
机译：在体外和体内研究了Ceriporia lacerata（CL）提取物和菌丝体的降血糖作用。用水和70％乙醇萃取CL的培养液。 CL提取物表现出对α-淀粉酶和α-葡萄糖苷酶的高抑制活性。与葡萄糖组相比，在用葡萄糖提取物和菌丝体进行的口服葡萄糖耐量试验中，补充葡萄糖60分钟后，葡萄糖水平分别降低了25.58和24.41％。将雄性SD大鼠分为正常对照组（NC），STZ诱导的糖尿病组（DM），STZ加CL提取物治疗组（DM-E）和STZ加菌丝体治疗组（DM-M）。与DM组相比，补充CL提取物和菌丝体可抑制血浆葡萄糖和脂质水平。此外，与DM组相比，DM-E组的丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平也分别降低，分别为62.08和59.83 IU / mL。因此，建议CL的提取物和菌丝体减轻糖尿病并发症。

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