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首页> 外文期刊>Food science and technology research >Effect of Acanthopanax sessiliflorus Extracts on Stress Response and Aging in Caenorhabditis elegans
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Effect of Acanthopanax sessiliflorus Extracts on Stress Response and Aging in Caenorhabditis elegans

机译：刺五加提取物对秀丽隐杆线虫的应激反应和衰老的影响

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摘要

Acanthopanax sessiliflorus has been used as traditional medicine in many diseases. The extracts from Acanthopanax sessiliflorus leaves were examined for their anti-oxidant activity in vivo. Resistance to oxi-dative stress was significantly increased by Acanthopanax sessiliflorus extracts. Since increased resistance to oxidative stress is commonly positively correlated with lifespan extension, we determined the effect of Acanthopanax sessiliflorus on lifespan of C. elegans. Both mean and maximum lifespan were markedly increased by Acanthopanax sessiliflorus extracts. In addition, the treatment of Acanthopanax sessiliflorus enhanced the survival of worms under heat stress. However, the reduced fertility or delayed reproduction period frequently accompanied with increased lifespan were not observed in Acanthopanax sessiliflorus-treated animals. These findings suggest that Acanthopanax sessiliflorus leaves can confer longevity pheno-type without reduced fertility, possibly through their anti-oxidant activity.
机译：刺五加已经在许多疾病中用作传统药物。检查了刺五加叶的提取物的体内抗氧化活性。刺五加提取物对氧化应激的抵抗力显着增加。由于增加的对氧化应激的抗性通常与寿命延长成正相关，因此我们确定了刺五加对秀丽隐杆线虫寿命的影响。刺五加提取物的平均寿命和最大寿命均显着增加。此外，刺五加的处理提高了蠕虫在热胁迫下的存活率。然而，在用五加刺五加处理的动物中未观察到生育力降低或繁殖周期延迟，并伴有寿命延长。这些发现表明，刺五加叶可以赋予长寿表型，而不会降低其生育力，这可能是由于其抗氧化活性。

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