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Novel Effects of Uridine on Behavioral Changes Due to Social Isolation Stress in Mice

机译：尿苷对小鼠社交孤立应激行为变化的新影响

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摘要

Uridine, a pyrimidine nucleoside present in many foods, is a modulator in the central nervous system. Uridine behaves as an anticonvulsant in a number of seizure models and also promotes sleep. In this study, we exposed mice to social isolation stress for 4 weeks and then investigated the effects of uridine on the changes induced by stress. Social isolation stress increased locomotor activity in an open field. This increase in locomotor activity was suppressed by uridine. Moreover, uridine prevented social isolation stress-induced aggressive behavior. To investigate how uridine administration modifies neurotransmitters, we estimated the concentration and release of neurotransmitters in the prefrontal cortex. Uridine modulated serotonin release. Our results suggest that uridine attenuates the behavioral changes due to social isolation stress in mice.
机译：尿苷是许多食物中存在的嘧啶核苷，是中枢神经系统的调节剂。尿苷在许多癫痫发作模型中起抗惊厥作用，并促进睡眠。在这项研究中，我们将小鼠暴露于社会隔离压力下4周，然后研究了尿苷对压力诱发的变化的影响。社会隔离压力增加了开放领域的运动能力。运动活性的这种增加被尿苷抑制。此外，尿苷可防止社交孤立压力引起的攻击行为。为了研究尿苷给药如何修饰神经递质，我们估计了额叶皮层中神经递质的浓度和释放。尿苷调节5-羟色胺释放。我们的结果表明，尿苷可减轻由于社交隔离压力引起的小鼠行为改变。

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  • 来源
    《Food science and technology research》 |2013年第3期|455-461|共7页
  • 作者

    Atsushi Kawasaki; Nobuyuki Suzuki; Kazuki Endo; Noriyuki Ashida;

  • 作者单位

    Biopharma Laboratory, Biochemicals Division, YAMASA Corporation, 2-10-1 Araoi-cho, Choshi, Chiba 288-0056, Japan;

    Biopharma Laboratory, Biochemicals Division, YAMASA Corporation, 2-10-1 Araoi-cho, Choshi, Chiba 288-0056, Japan;

    Biopharma Laboratory, Biochemicals Division, YAMASA Corporation, 2-10-1 Araoi-cho, Choshi, Chiba 288-0056, Japan;

    Biopharma Laboratory, Biochemicals Division, YAMASA Corporation, 2-10-1 Araoi-cho, Choshi, Chiba 288-0056, Japan;

  • 收录信息 美国《科学引文索引》(SCI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    nucleoside; uridine; stress; aggressive behavior; dopamine; serotonin;

    机译：核苷;尿苷;强调;攻击行为;多巴胺血清素;

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