• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Molecular Therapy. Nucleic Acids >MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice
【2h】

MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice

机译：MicroRNA-206调节断奶后社交隔离小鼠的激惹性攻击行为。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

When facing stressful conditions, some people tend to be impulsively aggressive whereas others are not. However, the causes and underlying mechanisms remain elusive. It has been reported that acute stress induces outbursts of aggression in post-weaning social isolation (SI) mice but not in group housing (GH) mice. Here we report epigenetic regulation of impulsive aggression in SI mice. At post-natal day 21, mice were randomly assigned to GH or SI groups. We found that SI mice exhibited a higher level of microRNA 206 (miR-206) compared with GH mice. Intra-hippocampal injection of AM206, an antagomir of miR-206, decreased stress-induced attack behavior in SI mice and increased BDNF expression. Moreover, BDNF expression was required for AM206 effects on the reduction of aggression. On the other hand, miR-206 overexpression in GH mice induced attack behavior. Intranasal administration of AM206 rather than a scramble control significantly reduced attack behavior and depression-like behavior in SI mice. Our results suggest that miR-206 mediates development of maladaptive impulsive aggression in early life adversity and that its antagomir could potentially be a therapeutic target against stress-exacerbated aggressive behavior.
机译：当面对压力大的环境时，有些人会冲动冲动，而另一些人则不会。但是，原因和潜在机制仍然难以捉摸。据报道，急性应激会在断奶后的社会隔离（SI）小鼠中诱发侵略性爆发，但在群居（GH）小鼠中则不会。在这里，我们报告SI小鼠冲动攻击的表观遗传调控。出生后第21天，将小鼠随机分为GH或SI组。我们发现与GH小鼠相比，SI小鼠表现出更高水平的microRNA 206（miR-206）。海马内注射miR-206 antagomir AM206，可减轻SI小鼠的应激诱导的攻击行为，并增加BDNF的表达。而且，BDNF表达对于AM206减少侵袭的作用是必需的。另一方面，GH小鼠中的miR-206过表达诱导了攻击行为。鼻内施用AM206而非加扰对照可显着降低SI小鼠的攻击行为和抑郁样行为。我们的研究结果表明，miR-206介导了早期逆境中适应不良的冲动攻击的发展，并且其antagomir可能是对抗应激加剧的攻击行为的治疗靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号