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首页> 外文期刊>Food science and technology research >Inhibition of Angiotensin-Converting Enzyme by Components of Traditional Mongolian Fermented Milk Products
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Inhibition of Angiotensin-Converting Enzyme by Components of Traditional Mongolian Fermented Milk Products

机译：蒙古族传统发酵乳制品成分对血管紧张素转化酶的抑制作用

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摘要

Several angiotensin-converting enzyme (ACE) inhibitory peptides have been detected in milk products. There are many traditional milk products in Mongolia. For this study, some Mongolian milk products were collected, and the ACE inhibitory activities of these samples were tested; an active fraction was found in aaruul made from mare's milk. After purification by dialysis and HPLC, the active fractions were isolated. The molecular weight of the active component was 362.05 M, as determined by mass spec-trometry. An authentic standard was used to determine the IC_(50) value of the inhibitory activity. From the results of molecular weight, the active component in aaruul was identified as 5'-GMP. The activity of 5'-GMP is not much higher than that of the active peptide in sour milk and some flavonoids. However, this is the first report that shows that 5'-GMP inhibits ACE activity. These results will provide useful information for the development of hypertension therapy agents.
机译：在乳制品中已检测到几种血管紧张素转化酶（ACE）抑制肽。蒙古有许多传统的牛奶产品。在这项研究中，收集了一些蒙古奶制品，并测试了这些样品的ACE抑制活性。在母马的牛奶制成的aaruul中发现了有效成分。通过透析和HPLC纯化后，分离出活性级分。通过质谱法测定，活性成分的分子量为362.05M。使用真实的标准物来确定抑制活性的IC_（50）值。从分子量的结果，将甘草中的活性成分鉴定为5'-GMP。 5'-GMP的活性并不比酸奶和一些类黄酮中活性肽的活性高很多。但是，这是第一个显示5'-GMP抑制ACE活性的报告。这些结果将为高血压治疗药物的开发提供有用的信息。

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  • 来源
    《Food science and technology research》 |2011年第6期|p.567-572|共6页
  • 作者

    Dolgorsuren Bayarsaikhan; Mayumi Ohnishi-Kameyama; Nobuya Shirai; Yoko Takahashi; Kohji Yamaki;

  • 作者单位

    Nutritional Function Laboratory, Food Function Division, National Food Research Institute, National Agriculture and Food Research Organization, Kannondai 2-1-12, Tsukuba, Ibaraki 305-8642, Japan,Clinical Nutrition Department, Shastin Central Hospital, Ard Ayush-la, 5th khoroo, Bayangol district, Ulaanbaatar, Mongolia;

    Mass Analysis Laboratory, Analytical Science Division, National Food Research Institute, National Agriculture and Food Research Organization, Kannondai 2-1-12, Tsukuba, Ibaraki 305-8642, Japan;

    Nutritional Function Laboratory, Food Function Division, National Food Research Institute, National Agriculture and Food Research Organization, Kannondai 2-1-12, Tsukuba, Ibaraki 305-8642, Japan;

    Nutritional Function Laboratory, Food Function Division, National Food Research Institute, National Agriculture and Food Research Organization, Kannondai 2-1-12, Tsukuba, Ibaraki 305-8642, Japan;

    Nutritional Function Laboratory, Food Function Division, National Food Research Institute, National Agriculture and Food Research Organization, Kannondai 2-1-12, Tsukuba, Ibaraki 305-8642, Japan;

  • 收录信息 美国《科学引文索引》(SCI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    traditional mongolian milk product; angiotensin-converting enzyme; 5'-guanosine monophosphate;

    机译：传统的蒙古奶制品;血管紧张素转换酶;5'-鸟苷一磷酸;

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